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Respiratory Drugs
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Albuterol (5)
AccuNeb (nebulizer)
ProAir
Proventil
Ventolin
VoSpire ER (tab)
SABA
Xopenex
Levalbuterol
SABA
Pirbuterol CFC
Maxair (breath-actuated)
SABA
Metaproterenol
Alupent (IV)
SABA
Isuprel
Isoproterenol
SABA
Brethine
Terbutaline (PO/SQ)
SABA
Formoterol (2)
Foradil (asthma) - DPI
Perforomist (COPD) - Nebulizer
LABA
Arformoterol
Brovana (COPD) - Nebulizer
LABA
Serevent
Salmeterol
LABA
Budesonide/Formoterol
Symbicort
Fluticasone/Formoterol
Advair Diskus
Dulera
Mometasone/Formoterol
QVAR
Beclomethasone (MDI)
ICS
Budesonide (2)
Pulmicort - DPI
Pulmicort Respules - Nebulizer
ICS
Fluticasone
Flovent - MDI
Flovent Diskus - DPI
ICS
Asmanex
Mometasone - DPI
ICS
Ciclesonide
Alvesco - MDI
ICS
Montelukast
Singulair
Leukotriene receptor antagonist
Accolate
Zafirlukast
Leukotriene receptor antagonist
Zileuton
Zyflo
5-Lipoxygenase inhibitor
Why is Singulair more popular than Accolate or Zyflo? (3)
Singulair has qd dosing vs BID/QID
Less adverse efx (Accolate, Zyflo increases LFTs)
Less DDI
Cromolyn
Intal - nebulizer
Mast cell stabilizer
Theophylline - Brand name? What is its drug class and its effects?
Theo-Dur
Methylxanthine
Increases cAMP and cGMP --> Bronchodilation
What is the desired therapeutic level of serum Theophylline?
5-15mcg/ml
Which CYP enzyme primarily metabolizes Theophylline?
CYP1A2
Omalizumab
Xolair
Immunomodulator
What is Xolair's MOA? How do you determine the dose? How is it administered and how often?
Binds to free Immunoglobulin E (IgE) in serum which prevents mast cell degranulation and release of inflammatory mediators
Dosing based on serum IgE levels and body weight
SC q2-4wks
What is COPD mainly caused by? (Makes it dfferent than asthma)
Noxious particles or gases
Which 1 of the 2 COPD conditions contains hypertrophy of goblet cells causing excessive mucus secretion?
Chronic bronchitis
Ipratropium
Atrovent
Short-acting anticholinergic
Tiotropium
Spiriva
Long-acting anticholinergic
What is the MOA of anticholinergics?
Blocks muscarinic ACh receptors (M1, M2, M3) for bronchodilation
Ipratropium + Albuterol
Combivent (COPD)
Based on UPLIFT trials, spiriva does not increase risks for stroke, heart attack or death. T/F
True
False
True
Roflumilast
Dialresp
PDE-4 inhibitor
pH
7.35-7.45
PO2
80-100mmHg
SaO2
95%
PCO2
35-45mmHg
HCO3
23-28mEq/L
FDA: Singulair is the only leukotriene modifier associated with behavior/mood changes, suicidal ideation, etc. T/F
True
False
False
ALL LM's have the FDA warning
Which drug should not be administered in nebulizer solution with Ipratropium due to formation of ppt?
Cromolyn (Intal)
COPD - Inflammation and structural changes increase with dz severity but will reverse upon smoking cessation. T/F
True
False
False
Smoking cessation will only decrease progression
Author
Snooze
ID
86490
Card Set
Respiratory Drugs
Description
Brands/generics/class of drugs
Updated
2011-05-18T08:35:37Z
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