osteoporosis drugs

  1. Indications of bisphonates?
    Pagets bone disease

    Prevention and treatment of osteoporosis (menopausal or corticosteroid induced)
  2. Precautions of Bisphosphonates?
    Upper GI conditions - dyspspsia or concominant use of NSAIDs

    renal impairment

    AF - can worsen AF
  3. contraindications of Bisphosphonates?
    Inability to sit upright or stand for 30 minutes after taking it

    Oesophageal disorders
  4. Side effects of Bisphosphonates?

    nausea, vomiting, diarrhoea, hypocalcaemia

    oesophageal erosions and ulcers, gastritis, rash

    osteonecrosis of the jaw
  5. Dose of alendronate?

    post menopausal osteoporosis?

    Prevention of osteoporosis?

    corticosteroid induced osteoporosis?
    10mg daily or 70mg a week

    5mg daily

    5mg daily, 10mg if woman not receiving oestrogen
  6. Counselling of alendronate?
    Take in the morning with a full glass of water at least 30 minutes before food or drink

    do not take antacids or calcium supplements

    if you have pain on swallowing or worsening heartburn, see your doctor

    tell doc if you get joint or muscle pain

    tell dentists that you are taking alendronate
  7. Dose of risendronate?
    5mg daily or 35mg a week
  8. Indications of calcitriol?
    treatment and prevention of osteoporosis

  9. Precautions of calcitriol?
    Treatment with digoxin - increases rick of arrhythmias

    Treatment with thiazide diuretics, increased risk of hypercalcaemia

    renal impairment - use active form
  10. Adverse effects of calcitriol?
    Nausea, vominiting, constipation, anorexia, headache
  11. Dose of calcitriol?
    0.25 micrograms twice daily for treatment of osteoporosis or prevention of corticosteriod induced
  12. Counselling of calcitiol?
    Do not take other calcium supplementation unless your doctor tells you to

    Keep dietary intake of calcium consistent

    May need blood tests every few months
  13. MOA of stronium?
    Increases bone formation and reduces bone resorption
  14. Indications for Strontium?
    Treatment of postmenopausal osteoporosis
  15. Precautions of stronium?
    • History of or increased risk of VTE -- increases risk
    • Renal impariment
  16. Adverse effects of stronium?
    • nausea, diarrhoea, headache, dermatitis
    • CNS effects (including disturbed consciousness, memory loss, seizures, confusion
    • VTE
    • DRESS -- life threatening allergic reaction occus within 3-6 weeks (rash, fever, swollen glands)
  17. Dose of stronium?
    2 g once daily at bedtime.
  18. counselling for stronium?
    • This medication is best taken at bedtime, at least 2 hours after eating, because food and drink (especially calcium-containing products such as milk) can reduce its absorption.
    • Mix the granules in water and drink immediately.
    • Seek medical advice promptly if you develop a rash while taking this medicine.
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osteoporosis drugs
osteoporosis drugs