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Description
Heparin is a rapid – acting anticoagulant prepared from bovine lung tissue or porcine intestinal mucosa.
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Mechanism of Action:
Heparin is a rapid-onset anticoagulant, enhancing the effects of antithrombin III and blocking the conversion of prothrombin to thrombin and fibrinogen to fibrin.
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Onset of Action:
Onset: Immediate Peak: 2-3 min Duration: 2-6 hours Half-life 90 min
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Indications
Heparin is used to inhibit clot formation in unstable angina and non-Q-wave myocardial infarction. Used to prevent pulmonary embolism, DVT.
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Contraindications
Hypersensitivity to the drug, to pork and beef products.
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Precautions
Do not use in patients with active major bleeding or thrombocytopenia. Caution in patients with chronic alcoholism and 3rd trimester pregnancies.
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Side
Effects
Bleeding complications, chest pain, confusion, dizziness, edema, rash
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Max Dose
Based on lab values
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Routes of Administration
IV/IO
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