Furosemide (Lasix)

  1. Trade Names
  2. Class
    Loop Diuretic
  3. Mechanism of action
    Inhibits electrolyte reabsorption and promotes excretion of sodium, potassium, chloride.
  4. Indications
    CHF, pulmonary edema, hypertensive crisis.
  5. Contraindications
    Hypovolemia, anurea, hypotension (relative conrtaindication); hypersensitivity, hepatic coma.
  6. Adverse reactions
    May exacerbate hypovolemia, hypokalemia, ECG changes, dry mouth, hypochloremia, hyponatremia, hyperglycemia (due to hemoconcentration).
  7. Drug interactions
    Lithium toxicity may be potentiated by sodium depletion. Digitalis toxicity may be potentiated by potassium depletion.
  8. How supplied
    100 mg/5 ml, 20mg/2 ml, 40 mg/4-ml vials.
  9. Dosage and Administration
    • Adult: 0.5-1.0 mg/kg injected IV over 1 to 2 minutes. If no response, double the dose to 2 mg/kg over 1 to 2 minutes.
    • Pediactric: 1 mg/kg/dose IV, IO.
  10. Duration of action
    • Onset: 5 minutes
    • Peak effects: 20-60 minutes.
    • Duration: 4-6 hours.
  11. Special considerations
    Pregnancy safety: Category C. Ototoxicity and deafness can occur with rapid administration. Should be protected from light.
Card Set
Furosemide (Lasix)
Paramedic Pharmacology