Pharmacology

its a measure of the danger of poisoning, the higher it is the safer the drug is. Its a ratio of a therapeutic dose to one that is toxic.

It means that the drug has reached the circulation and is therefore avaliable to all the tissues.

A drug that produces a response

A drug that inibits a response

• It can yield much information about a drugs mechanisms of action and its potency. it can tell us about
• *the drugs potency
• *efficacy
• *action as an antagonist

• *increase in force and rate of contraction of the heart
• *a rise in systolic blood pressure due to increased cardiac output
• *adrenaline relaxes smooth muscle including the bronchial tree
• *adrenaline raises blood sugar by mobilising glucose from the tissues

Its most important action is to produce widespread vasoconstriction - and hence a rise in both systolic and diastolic blood pressure

• Used to treat asthma, it is a agonist.
• -powerful bronchodilator.
• -In large doses it can cause tremor and tachycardia, and occasionally night cramps