Benign Lymphadenopathy

Which is worse, B/L and tender LN, or unilateral and nontender LN?

LN neoplasm cytology

Reactive LN cytology

Vary in size, shape and number of follicles; seen
often in children and adolescents

Tingible body macrophages

Unilateral posterior lymph nodes are commonly affected

What are LN characteristics in toxoplasmosis lymphadenitis?

What cells are predominant in toxoplasmosis lymphadenitis?

Associated with plasma cells and perivascular location

Epithelial histiocytes, thick capsule of the lymph node, with plasmacytic and lymphocytic infiltrate

When are spirochetes present in blood vessels in syphilis?

Solitary inguinal lymphadenopathy

Four types of granulomatous lymphadenitis

Necrosis and aggregates of macrophages with “C” shaped nuclei and CD8+ immunoblasts in interfollicular areas

Necrotic areas with karyorrhectic debris and paucity (low number) of neutrophils

Plasmacytoid monocytes with round nuclei and eosinophilic cytoplasm

What population does Kikuchi dz affect?

Kikuchi dz is similar to what other dz?

Discrete well circumscribed, non-caseating epitheliod granulomas

Asteroid and Schaumen bodies

Suppurative (pus) granulomas with stellate (star-shaped) abscesses surrounded by pallisading macrophages and histiocytes especially in germinal centers

What type of hyperplasia is evident in cat-scratch dz?

Cause of cat-scratch

Found in immunocompromised hosts with dermal lesions, increased capillaries, plump endothelial cells, granular eosinophilic material containing the organism

Negative silver stain

Inguinal lymphadenopathy, presence of chlamydia, hx of sexual activity and burning with urination

Lymphogranuloma venereum resembles what?

Extravasation of RBC’s into the germinal centers, mantle zones are the areas around the follicles

cells with multiple nuclei and eosinophilic intranuclear inclusions

Follicular hyperplasia florid and termed explosive

geographic pattern/geographic follicles

What can cause a diffuse pattern?

Reactive follicles with marked interfollicular expansion and mottled appearance (slightly resembling Reed Sternberg cells)

Mottled vascular mixed cell infiltrate

Fever, erythematous rash and eosinophilia

Prominent lymphocytic hyperplasia with a background of macrophages

Follicular hyperplasia, interfollicular plasmacytosis similar to syphilis

Having RA puts you at risk for what?

Which form of castleman disease is more common?

Mantle zone hyperplasia with concentric layering of cells giving an onionskin pattern

Vessels penetrate into the germinal center resembling a lollipop

Two or more germinal centers with hyalinized vessels

Herpes virus 8 is linked to what conditions

sinus histiocytosis with massive lymphadenopathy (B/L nontender cervical nodes)

Histiocytes, S100+, macrophages with emperipolesis

Nodes matted together from fibrosis (over months to years)

Foamy macrophages and sickle shaped bacillary organisms

Hyperpigmentation of the skin with CNS changes – depression, stupor, confusion

Chief complaint in a Whipple Dz pt

Younger children with pancytopenia and constitutional symptoms

Bland macrophages seen in lymph nodes; macrophages ingest RBC, neutrophils, and platelets

Paracortical/interfollicular expansion of large cells

Pigment laden macrophages, similar to mycosis fungoides or lymphoma

Lymphadenopathy, splenomegaly; hypergammaglobulinemia

Genetic type mutation of FAS(CD95),generally activates apoptosis

Increase CD5+ B cells in peripheral blood

Paracortical follicular hyperplasia with transformation
of germinal centers

ALPS pts have an increased risk for what?

Give the example of a lymphoproliferative DO with the potential to turn into a lymphoma

Kawasaki Disease is AKA what?

Conjunctivitis, coronary artery involvement, affects kids

Nodal architecture obliterated, lymphoid depletion and absence of follicles