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Mechanism of action
Smooth muscle relaxant acting on vascular, bronchial, uterine, and intestinal smooth muscle; dilation of arterioles and veins in the periphery; reduces preload and afterload; decreases the work load of the heart and, thereby, myocardial oxygen demand.
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Indications
Acute angina pectoris, ischemic chest pain, hypertension, CHF, pulmonary edema.
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Contraindications
Hypotension, hypovolemia; intracranial bleeding or head injury; previous administration of Viagra, Revatio, Levitra, Cialis, or similar agents within past 24 hours.
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Adverse reactions
Headache, hypotension, syncope, reflex tachycardia, flushing, nausea, vomiting, diaphoresis, muscle twitching.
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Drug Interactions
Additive effects with other vasodilators; incompatible with other drugs IV.
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How supplied
- Tablets: 0.15 mg (1/400 grain); 0.3 mg (1/200 grain); 0.4 mg (1/150 grain); 0.6 mg (1/100 grain).
- NTG spray: 0.4 mg-0.8 mg under the tongue.
- NTG IV (Tridil).
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Dosage and Administration
- Adult: Tablets; 0.3-0.4 mg SL; may repeat in 3-5 minutes to maximum of 3 doses.
- NTG spray : 0.4 mg under the tongue; 1-2 sprays.
- NTG IV infusion: begin at 10 to 20 mcg/min; increase by 5-10 mcg/min every 5 minutes
- until desired effect.
- Pediatric: Not recommended.
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Duration of action
- Onset: 1-3 minutes.
- Peak Effect: 5-10 minutes.
- Duration: 20-30 minutes or if IV, 1-10 minutes after discontinuation of infusion.
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Special Considerations
Pregnancy safety: Category C. Hypotension more common in geriatric poulation. NTG decomposes if exposed to light or heat. Must be kept in airtight containers. Active ingredient may have a stinging effect when administered.
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Trade Names
Nitrostat, Tridil
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