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Renal Physiology
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What percentage of cardiac output is renal blood flow?
20% or 1200 mL/min
Majority of renal blood flow goes where?
cortex
Renal blood flow is regulated by what?
hormones
What 6 factors increase blood flow?
Nitrous oxide
Dopamine
Prostaglandins
Histamines
Bradykinin
Serotonin
What 7 factors decrease renal blood flow?
Thromboxanes
Endothelin
Norepinephrine
Epinephrine
Leukotrienes
ATI
ATII
Adenosine
Normal GFR
mL/min?
L/d ?
120 mL/min
180 L/d
What is GFR dependent on?
permeability of the capillary wall surface area available for filtration
How much urine does the average person produce?
1.5 L urine/day
Where does most of the work happen? Before or after the glomerulus?
Before - most gets reabsorbed
What is normal RBF?
70-180 mmHG of systolic blood pressure
How does the tubuloglomerular feedback work?
Blood pressure is increased
Increases GFR
NaCl to macula densa (collecting system)
Afferent arterioles constrict
Decrease GFR
(to decrease BP decrease NaCl)
How does the myogenic theory work?
Vasoactive factors from the arteriolar endothelium maintain a constant rate in response to BP changes
What part of the tube stays constant despite blood pressure and glomerular filtration rates?
PCT (proximal convoluted tubule)
What osmotic state is found in the PCT (proximal convoluted tubule)?
isotonic
What is the main aspect of PCT (proximal convoluted tubule)?
Na transport
What osmotic state is found in the loop of henle?
Hypotonic
What is resorbed in the loop of henle?
Ca
Mg
What is the osmotic state in the DCT (distal convoluted tubule)?
Hypotonic
What follows sodium?
Chloride
In which part of the tube is water impermeable?
DCT (distal convoluted tubule)
Where is most K reabsorbed?
PCT (proximal convoluted tubule)
Where is the primary site of ADH action?
Collecting duct
What are the 5 main homeostatic functions of the kidney?
HE BE GE WE
Hormone regulation
BP regulation
Glucose homeostasis
Waste excretion
Author
Anonymous
ID
8432
Card Set
Renal Physiology
Description
Renal Physiology
Updated
2010-02-28T17:10:04Z
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