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Status asthmaticus
doesn't respond to bronchidilation, switches to respiratory acidosis=>resp failure
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Asthma most common chronic disease of childhood, can occur at any age
Extrinisic factors?
Intrinsic factors?
- Extrensic: Allergy (strongest), seasonal or perennial, chronic exposure to airway irritants (smoke pollutants cold heat weather changes, strong odors or perfumes).
- Intrinsic factors: resp inf, ex induced, meds- stress emo upset, fatigue, GERD, ace inhibitors
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-What sends mast cells?
-Chemical mediators causing vasodilation, fluid leak, WBC accum, cap permeability and bronchoconstriction
-asthma tx aimed at...:
- -IgE
- -histamine, leukotreines, prostaglandins and other chem meds
- ...why anything other than bronchodilators not for emergency, can only prevent, not reverse
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Why glucocorticoids so effective tx asthma
prevents so much of immune response. Even prevents IgE from getting involved.
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-#1 recurr asthma attacks?
-sx of impending attack
- -miss scheduled meds.
- -inc need for albuterol, act. lims, frequent waking, variability in peak flow rate
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Classic asthma sx
dyspnea, wheezing, (bronchospasms leading to) coughing
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Prog asthma exacerbation sx include
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