Poly- means: and -oma means:
Polyomavirus virion is __?__.
Polyoma- genome is __?__.
Circular dsDNA packaged as "
" with nucleosomes formed from celllular histones
Polyoma- genes are transcribed in __?__ which are called __?__.
in two units
early (regulate cycle/direct DNA rep) and late (Virus capsid VP1, 3, and 3)
Examples of Polyoma include: __?__
BK and JC virus
Polyoma distinct characteristics include :__?__ (X4)
dependant on cellular RNA synthesis and RNA processing enzymes and DNA rep machinery
T antigens are oncogenes that can transfrom nonpermissive cells in vitro (
binds pRb and p53
pRb and p53 are __?__/
They are both tumor supressor genes. By deactivating them the virus induces cell proliferation so it can be replicated.
Does so without letting p53 put the cell into apoptosis
The T antigen __?__ p53 trx and __?__ pRb.
inhibits pRb which is a trx factor usually bound to DNA preventing trx. (
inhibiting pRb activates trx