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therapy cancer test 2
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Ovarian Cx Risk Factors
Few or no children
older age at marriage
older age at first birth
late menopaus
genetic syndromes (BRCA1/BRCA2, HPNCC/Lynch Syndrome)
Things that decrease risk of Ovarian CX
lots of children
breast feeding
oral contraceptive use
Prophylactic oophorectomy in high risk patients
Tumor Marker for Ovarian Cx
CA-125
Flowchart for who gets chemo for Ovarian Cx
Adjuvant Chemo for Ovarian Cx
Taxane
: Paclitaxel vs Docetaxel
Platinum
: Cisplatin vs Carboplatin
SE Diff between Paclitaxel vs Docetaxel in Ovarian CX
Paclitaxel - more neuropathy
Docetaxel more severe neutropenia
SE Diff between Cisplanin vs Carboplatin in Ovarian CX
Carbo - fewer SE in general, but more myelosuppression, esp thrombocytopenia
Cis- more neprhotoxicity and neuropathy
How is ovarian chemo given
interperotineally but still goes systemic
Options for Adjuvant Ovarian Chemo
Which should you give first, paclitaxel or platinum?
Paclitaxel
Pay your taxes first
cisplatin decreases paclitaxel clearance
Calvert equation
(target AUC)x(GFR+25)=total dose in mg
Used for carboplatin
Use Cockcroft and Gault OR Jellife equation for GFR
CAP GFR ESTIMATE AT 125ML/MIN
Why use calvert formula with carbo
Decrease toxicity
Increase efficacy
Tax/Plat Sensitive patients who relapse after 6 months
Treatment for Tax/Plat resistant Ovarian CX
topotecan(most likely)
liposomal doxorubicin (most likely)
Docetaxel
Gemcitabine
Paclitaxel weekly low dose
etoposide PO
Author
krug0043
ID
83656
Card Set
therapy cancer test 2
Description
cancer
Updated
2011-05-04T03:55:03Z
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