Dextrose (D50)

  1. Class
    Carbohydrate, hypertonic solution
  2. Mechanism of Action
    Rapidly increased serum glucose levels. Short term osmotic diuresis.
  3. Indications
    Hypoglycemia, altered level of consciousness, coma of unknown etiology seizure of unknown etiology, status epilepticus.
  4. Contraindications
    Intracranial hemorrhage.
  5. Adverse Reactions
    Extravasation leads to tissue necrosis. Warmth, pain, burning, thrombophlebitis, rhabdomyolysis, hyperglycemia.
  6. Drug Interactions
    Sodium bicarbonate, Coumadin.
  7. How Supplied
    25g/50-ml prefilled syringes (500 mg/ml).
  8. Dosage and Administration
    • Adult: 12.5-25 g slow IV; may be repeated as necessary.
    • Pediatric: 0.5-1 g/kg/dose slow IV; may be repeated as necessary.
  9. Duration of action
    • Onset: less than 1 minute.
    • Peak effect: variable
    • Duration: variable
  10. Special considerations
    Administer thiamine prior to D50 in known alcoholic patients. Draw blood to determine glucose level before administering. Do not administer to patients with known CVA unless hypoglycemia documented.
Card Set
Dextrose (D50)
Paramedic Pharmacology