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Types of CV Disorders (7)
- Myocardial infarction
- Congestive Heart Failure
- HTN
- Angina
- Arrhythmias
- Hyperlipidemia
- Stroke
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Alpha 1 Adrenergic Blockers (3)
- Doxazosin - Cardura
- Terazosin - Hytrin
- Tamsulosin
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Alpha 1 MOA
- Blocks A1 receptors.
- Causes dilation of peripheral arterioles and veins
- Relaxes smooth muscle
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Alpha 1 blockers counseling points (4)
- SE: orthostatic hypotension
- Titrated dosing
- May take 1-2 weeks to stabilize
- Preg Cat C
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Alpha 2 adrenergic blockers (1)
Clonidine - Catapres
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A2 indications
- HTN (not first line)
- ADHD (ER only)
- Off label stuff
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A2 MOA
- Stimulates A2 receptors in brainstem
- Reduces symp output
- Decreased peripheral resistance, heart rate and BP
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A2 counseling points
- SE: orthostatic hypotension and CNS depression
- Same as A1
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Nitrates (3)
- Nitroglycerin
- Isosorbide mononitrate - ISMO, Monoket
- Isosorbide dinitrate - Isordil
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Nitrates indications
- Angina pectoris
- HTN
- Hearth failure
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Nitrates MOA
- Stimulate intracellular cGMP production
- Vasodilation
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Nitrates counseling points
- SE: Flushing
- For acute angina, if pain persists after 5 mins call 911. May take up to 3 tablets.
- Store SL tablets in tinted glass bottle
- Preg Cat B/C
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Antiarrythmics (1)
Amiodarone - Cordarone, Pacerone
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Antiarrythmics MOA
- Block Na+ channel: slow intraventricular conduction
- Block Badrenergic/Ca2+ channels: slow AV node conduction
- Inhibits K+ channel: prolonged repol
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Antiarrythmics counseling points
- SE: bradycardia, N/V/Dizziness, hypothyroidism, photosensitivity
- Take with food
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Antiarrythmics Toxicity
- Liver toxicity
- Usually mild
- Blue/gray skin
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Antiarrythmics 2 (1)
Digoxin - Lanoxin
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Antiarrythmics 2 Indications
- Hearth Failure (CHF)
- Supraventricular arrhythmias
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Antiarrythmics 2 MOA
- Inhibits Na+/K+/ATPase pumps
- Normalizes HR and decreases conduction via AV node
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Antiarrythmics 2 Counseling Pointsq
- SE: blurred vision, yellow/green halos
- Take with lots of water
- Tons of DDI
- Narrow therapeutic index
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Antithrombolytics (3)
- Warfarin - Coumadin
- Clopidogrel - Plavix
- Aspirin
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Antithrombolytics MOA
- Warfarin - inhibit formation of vitamin K clotting factors
- Clopidogrel - irreversibly binds to ADP receptors on platelets
- Aspirin - covalently binds to COX enzymes
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Warfarin Counseling points
- SE: bleeding, blood in stool
- No EtOH
- Avoid chances in diet (green leavy vegetables)
- Do not DC abruptly
- Narrow therapeutic index
- Preg Cat X
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Clopidogrel Counseling points
- SE: Bleeding, blood in stool
- Avoid NSAIDS
- Avoid Omeprazole, decreases effect
- Preg Cat B
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Aspirin Counseling points
- SE: N/V/D GI stuff
- CI in children
- Preg cat D in 3rd trimester
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