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Basis for selection of psychotropic drugs (5):
- Availability
- General Behavioral Actions
- Side Fx
- Reported Therapeutic Fx
- Neurochemistry
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FDA approved psychotropics (3)
- Clomipramine
- Fluoxetine
- Selegiline
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Which FDA approved drugs are used to tx separation anxiety in dogs (2)? What do they act on?
- Clomipramine (Serotonin & Norepi)
- Fluoxetine (Serotonin)
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What FDA Approved drug is used to treat canine cognitive dysfunction? What does it act on?
Selegiline, MOAf
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What areas of the brain does serotonin act on & what are the effects (4)?
- Limbic Areas- anxiety & panic
- Basal Ganglia- compulsive disorder
- Frontal Cortex- mood
- Neurons of the brainstem- sleep
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General effects of Serotonin (3):
- Anti-Anxiety
- Anti-compulsive
- Behavioral calming effect
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Fx & Side Fx of Acepromazine in...
Dogs (3):
Cats (2):
- Dogs:
- Useful in some cases
- Traquilizer
- No anti-anxiety
- Cats:
- Traquilizer
- No anti-anxiety
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Fx & Side Fx of Diazapam in...
Dogs: (2)
Cats: (2)
- Dogs:
- Rapid Metab
- May release inhibition
- Cats:
- Sedation
- Hepatic Necrosis
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Fx & Side Fx of Busperone (Buspar) in...
Dogs (2):
Cats (2):
- Dogs:
- Mild GIT Fx
- Social Behavior Changes
- Cats:
- Mild GIT Fx
- Social Behavior Changes
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Fx & Side Fx of Amitryptyline(Elavil) in...
Dogs (3):
Cats (2):
- Dogs:
- Mild Sedation
- GI Fx
- Anti-Cholinesterase
- Cats:
- Mild Sedation
- Anti-Cholinesterase
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Fx & Side Fx Paroxetine (Paxil) in...
Dogs(2):
Cats(2):
- Dogs:
- Anti-cholinesterase
- Restlessness
- Cats:
- Anti-cholinesterase
- Restlessness
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Fx & Side Fx of Clomipramine (clomicalm) in...
Dogs(2):
Cats(2):
- Dogs:
- Mild Sedation
- Vomiting on an empty stomoch
- Cats:
- Mild Sedation
- Vomiting on an empty stomach
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Fx & Side Fx of Fluoxetine (Prozac) in...
Dogs:
Cats (2):
- Dogs:
- Cats:
- Anti-Choliesterase
- Sleepiness
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Azasperones:
Burspirone (Buspar)
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Tricyclic Antidepressants (2):
- Amitriptyline (Elavil)
- Clomipramine (Clomicalm)
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SSRI (2):
- Paroxetine (Paxil)
- Fluoxetine (Prozac)
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What Drugs can be used to Tx fear/phobias in dogs (3)?
- Diazapam
- Transene (Cloirazepate Dipotassium)
- Alprazolam
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What Drugs are used to Tx general anxiety in dogs (3)?
- Azapirones
- Loarzapam (geriatrics)
- SSRI
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What Drugs are used to Tx Seperation Anxiety in dogs (3)?
- Diazapam
- Clomipramine HCl (Clomicalm)
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What Drugs are used to Tx Anxiety in cats (4)?
- Azapirones
- Clomipramine HCl (Clomicalm)
- Diazepam
- SSRI's
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What drugs are used to Tx urine spraying in cats (4)?
- Diazapam
- Azapirones
- SSRI
- Clomipramine HCl (Clomicalm)
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What durgs are used to Tx Compulsive Behaviors in dogs (2)?
- SSRI's
- Clomipramine HCl (Clomicalm, Tricyclic)
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What drugs are used to Tx Sleep Disorders in dogs?
MOI's
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What drugs are used to Tx Cognitive Dysfunction in dogs?
MOI's
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What drugs are used to Tx depression in dogs and cats?
Fluoxetine (SSRI)
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What drugs are used to Tx eating disorders in dogs and cats?
Fluoxetine (SSRI)
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What drugs are used to Tx panic disorders in dogs and cats?
Fluoxetine (SSRI)
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What drugs is used to Tx urine marking in Dogs and Cats?
Amitriptyline
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What drugs are used to Tx hyperesthesia in cats?
Clomipramine HCl (Clomicalm, Tricyclic)
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What drugs are used to Tx Acral Lick Dermititis in dogs
Clomipramine HCl (Clomicalm, Tricyclic)
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What Drugs are used to Tx tail chasing/flank sucking in dogs?
Clomipramine HCl (Clomicalm, Tricyclic)
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What drugs are used to Tx aggression?
SSRI
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Tricyclic Antidepressants can be used with _(3)__ when single drug Tx's fail
- Benxodiazapines
- Buspirone
- Trazadone
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SSRI's can be used with _(2)__ when single drug Tx's fail
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Benzodiazapines can be used with _(2)__ when single drug Tx's fail
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Baseline psychotrpoic drugs (3):
- (Benzodiazapines)
- Alprazolam
- Lorazepam
- Chlorazepam
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Atypical psychotropic Drugs (2):
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What drug can cause mortalities d/t cardiac abnormalities?
Citalopram
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What is the 1/2 life for Fluoxetine HCl (Prozac)?
4-16 days
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MOI's should not be given with... (2)
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TCA's should not be given with... (3)
- Cimetidine
- Amitraz
- Ketconazole
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What should no be given with TCAs b/c it inhibits cytochrome P-450?
Cimetidine
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What drugs can cause serotonin syndrome?
MOI's + Mitaban Dip, Preventic Collars, TCA or SSRI's
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What drugs affect learning processes (necessary for behavior modificiation)?
- Benzodiazapines
- Phenothiozines
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What drugs may facilitate learning?
TCA's
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