1. What is the presentation of aspirin?
    300mg chewable tablet

    • 300mg soluble or water dispersible tablets
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  2. What is the pharmacology of aspirin?
    • Anti-inflammatory
    • Antipyretic
    • Antiplatelet aggregation agent
    • Analgesic

    • Actions: reduces platelet aggregation
    • inhibits synthesis of prostaglandins (anti-inflammatory)
  3. How is aspirin metabolised?
    Converted to salicylate in the gut mucosa and liver

    Excreted mainly by the kidneys
  4. What is the primary emergency indication for aspirin?
    To minimiae platelet aggregation and thrombus formation in order to retard the progression of coronary artery thrombosis in acute coronary syndrome
  5. What are the contraindications for aspirin?
    • Hypersensitivity
    • Actively bleeding peptic ulcers
    • Bleeding disorders
    • Suspected dissecting AA
    • Chest pain associated psychostimulant overdose if BP >160
  6. What are the precautions for giving aspirin?
    • Peptic ulcers
    • Pts on anticoagulants e.g. warfarin
    • Asthma
  7. How is aspirin administered?
  8. What are the side effects of Aspirin?
    • Nausea
    • Heartburn
    • GI bleeding
    • Increased bleeding time
    • Hypersensitivity reactions
  9. Special notes and times of Aspirin
    Do not give to children or adolescents with acute febrile illness

    Anitplatelet effects last for the life of the platelet 8-10 days
Card Set
Aspirin pharmacology guideline