1. Indications for olanzapine?

    bipolar - adjunct to valproate or lithium
  2. Precautions of antipsychotics?
    parkinsons - may worsen symptoms (consider clozapine instead)

    Epilepsy - may lower seizure threshold

    Prolonged QT interval - may cause arrhythmias
  3. Adverse effects of antipsycotics?
    sedation, anxiety, agitation, anticholinergic effects.

    SIAHD, anaemia, thrombocytopaenia
  4. Which antipsychotics have an increased risk of diabetes through increase blood glucose levels?

    What else do they increase the risk of?
    Clozapine and olanzapine, (quietapine?)

    Dyslipidaemia and weight gain
  5. Which antipsychotic causes skin reactions?
  6. Which antipsychotics can increase the risk of stroke when used in patients with dementia?
    arirprazole, olanzapine, risperidone.
  7. Dose of olanzapine?
    10mg once daily, increase by 2.5mg to 20mg
  8. Counselling for olanzapine
    Tell your doctor if you stop smoking since your dose may need adjusting

    Take medication regularly, even if you fele better

    Avoid illicit substances

    You may feel dizzy on standing, get up slowly.
  9. Indications for quietapine?


    Adjunct in refractory depression

    Generalized anxiety disorder
  10. dosage of quietapine?
    25mg twice daily (upto 200-400mg twice daily) - skitz

    50mg twice daily to 200mg twice daily (upto 800mg daily) for bipolar
  11. Dose of risperidone?
    1mg twice daily increasing upto 4-6mg daily (0.5mg daily if elderly or renally impaired)
  12. Indications of lithium?
    • Prevention of manic or depressive episodes in bipolar disorder
    • Treatment of acute mania
    • Schizoaffective disorder and chronic schizophrenia
  13. Precautions of lithium?
    • Hyponatremia - increased lithium toxicity
    • psoriasis - can exacerbate
    • Treatment with drugs that can cause serotonin toxicity
    • Renal impairment
  14. Adverse effects of lithium?
    metallic taste, nausea, diarrhoea, weight gain, fatigue, headache, vertigo, tremor, psoriasis,
  15. Dose of lithium?
    acute mania?
    • acute mania: 750-1000mg daily in divided dose with food. max dose is 2500 daily
    • 250-1000mg in divided daily doses for prophylaxis
  16. Counselling for lithium?
    • Regular blood tests (renal and thyroid function)
    • Be alert for signs and symptoms of lithium toxicity (eg extreme thirst and frequent urination, nausea and vomiting), especially during illness, excessive sweating or low fluid intake; if these occur, stop taking the
    • tablets and seek medical attention immediately.
    • avoid taking with hot drinks.
    • Maintain a normal diet with regular salt and fluid intake.
    • Drink more fluid during hot weather to avoid toxicity.
    • Avoid sodium bicarbonate (found in products such as indigestion medicines, eg Salvital®, and products like Ural®, Citralite® or Citravescent®) as it makes lithium less effective.
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