Pharmacology Final

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Uses for methylprednisolone
- ocular inflammation
- otitis externa
- inflammatory musculoskeletal conditions
- ulcerative colitis
- nephrosis
ADEs with methylprednisolone
- fluid and e- imbalance
- sodium retention
- HTN
- potassium loss/alkalosis
- Increases in ALT and AST
Drug interactions with methylprednisolone
- Drugs that induce hepatic enzymes
- Phenobarb
- Phenytoin
- Rifampin
- Ketoconazole
- Troleandomycin
Triamcinolone indication
- adrenal cortex insufficiency
- inflammatory disorders
- allergic disorders
- connective tissue disorders
Mechanism of action for triamcinolone

reduces inflammation by modifying the body's immune response
May decrease effectiveness of triamcinolone
- Inducers of cyp enzymes
- barbiturates
- carbamazepine
- phenytoin
- rifampin
Severe ADEs with triamcinolone
- severe allergic reaction
- black tarry stool
- changes in menstrual periods
Common ADEs with triamcinolone
- bone fractures
- change in appetite
- change in mood
Ketoconazole Indications
- Systemic infections in pt who have not responded to topical therapy or oral griseofulvin.
- candidiasis
- oral thrush
- candiduria
Ketoconazole mechanism of action

adrenal steroid inhibitor
Ketoconazole should not be used for

fungal meningitis because it penetrates poorly into the CSF
ADEs with ketoconazole
- photophobia
- diarrhea
- gynecomastia
Ketoconazole drug interactions

potent inhibitor of CYP 3A4
Mitotane indications

inoperable adrenal cortical carcinoma
Mitotane ADEs
- Anorexia
- n/v
- diarrhea (80% of pt)
40% of pt on mitotane experience

CNS ADEs
15% of pt on mitotane experience

skin toxicity
25% of pt on mitotane experience

somnolence
15% of pt on mitotane experience (CNS effect)

Dizziness or vertigo
Drug interactions with mitotane

accelerates metabolism of warfarin

Author

Rx2013

81934

Card Set

Pharmacology Final

Description

Glucocorticoids 2

Updated

2011-04-26T16:07:37Z

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