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Pathogens
Harmful organisms and viruses that can cause disease.
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Phases of Defense Response (3)
- Recognition Phase - the organism must be able to distinguish self and non self
- Activation Phase - leads to the movement of cells and molecules to fight the invader
- Effector Phase - the mobile cells destroying the invader cells
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Types of Defense Mechanisms (2)
- Nonspecific (innate) defenses
- Specific (adaptive) defenses
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Nonspecific (innate) defenses
- provide the first line of defense
- acts within minutes to hours
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Specific (adaptive) Defenses
- aimed at specific pathogens
- can make a specific target protein to destroy a specific pathogen
- develop slowly and are long lasting
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Blood Plasma
- solution containing ions, molecular solutes, soluble proteins
- suspended in the plasma; RBCs, WBCs, Platelets
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Lymph
- fluid derived from blood and other tissues in the intercellular spaces
- moves through the vessels of the lymphatic system
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Lymph Nodes
sites along the lymph vessel that contains lymphocytes that filters lymph and activates an immune response
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Lymphocytes
- a type of white blood cell in lymph nodes
- they encounter foreign cells and initiate immune response
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Types of White Blood Cells (2)
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B Cells and T Cells
- types of lymphocytes
- smaller than phagocytes
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Antibodies
- Proteins that bind to specific substances IDed by the immune system
- "nonself / altered self"
- can inactivate viruses and toxins
- produced by B Cells
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Major Histocompatibility Complex (MHC)
- proteins important for self IDing labels
- play major role in coordinating interactions between lymphocytes and macrophages
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T Cell Receptors
- integral membrane proteins
- recognize and bind to nonself substances
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cytokines
- soluble signaling proteins
- released by many cell types
- they alter the behavior of their target cells
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Normal Flora
- bacteria and fungi that normally live in great numbers on our bodies
- don't cause disease
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lysozyme
- enzymes in the nose and other system
- attacks the cells walls of many bacteria and causes them to explode
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complement proteins
- antimicrobial proteins
- have a characteristic sequence
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interferons
- signaling proteins
- increase resistance to infection
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mast cells
- the first responders to tissue damage
- release chemical signals
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