Pharmacology Final

  1. Adrenocorticoid Production
    hypothalamus => anterior pituitary => ACTH acts on Adrenal Cortex => Cortisol
  2. Effects of glucocorticoids on metabolism
    • stimulaiton of gluconeogenesis
    • mobilization of amino acids from extra hepatic tissue
    • inhibition of glucose uptake in muscle and fat
    • stimulation of fat breakdown
  3. Effects of glucocorticoids on inflammation and immune function
    potent anti-inflammatory & immunosuppressant
  4. Disease states associated with glucocorticoids
    • Cushing's disease
    • Addison's disease
  5. Hyperadrenocorticism
    • cushing's disease
    • excessive endogenous cortisol production
    • administer glucocorticoids for therapeutic purposes
  6. Hypoadrenocorticism
    • Addison's disease
    • result of infectious disease or autoimmune destruction of the adrenal cortex
  7. Dexamethasone
    • synthetic glucocorticoids
    • anti-inflammatory/immunosuppressant
  8. Signs of dexamethasone overdose
    • retinal toxicity
    • glaucoma
    • subcapsular cataract
    • GI bleed
    • pancreatitis
  9. Hydrocortisone
    • most important human glucocorticoid
    • essential for life
    • regulates/supports CV, metabolic, immunologic and homeostatic functions
  10. Indications for hydrocortisone
    relief of inflammatory and pruritic manifestations of dermatoses
  11. Mechanism of action for hydrocortisone
    binds to the cytosolic glucocorticoid receptor
  12. ADEs with hydrocortisone
    • inhibition of bone formation
    • suppression of calcium absorption
    • delayed wound healing
  13. Prednisonlone
    synthetic glucocorticoid
  14. Prednisonlone indication
    • primary or secondary adrenocortical insufficiency
    • psoriatic arthritis
    • arthritis
  15. Prednisonlone mechanism of action
    • inhibits leukocyte infiltration at the site of inflammation
    • interferes with mediators of inflammatory response
    • suppress humoral immune responses
  16. ADEs with prednisolone
    • high blood glucose levels
    • fluid retention
    • cushing's syndrome
  17. all glucocorticoids are contraindicated in
    systemic fungal infections
  18. Methylprednisolone indications
    • 1' or 2' adrenocortical insufficiency
    • congenital adrenal hyperplasia
    • non suppurative thyroiditis
    • hypercalcemia associated with cancer
    • dermal conditions
Author
Rx2013
ID
81681
Card Set
Pharmacology Final
Description
Glucocorticoids Part 1
Updated