what is it called when a cell dies as normal part of life and not occur in malignancy?
apoptosis
_____ is associated with aplification of oncogens
malignancy
malignancy is associated with _______ of ______
amplification of oncogenes
what does the cell cycle phase-specific chemotherapeutic agents kill?
cells progressing through active phases of reproductive cell cycle
t/f in malignant cells apoptosis occurs
false, no cell death-malignant cells continue to grow
what drug inhibits proliferation of breast cancer cells?
trastuzumab (Herceptin)
what is an example of a monoclonal antibody therapy?
trastuzumab (Herceptin)
what are the ADE of chemothereapy agents? 4
suppression of bone marrow
gastrointestinal disturbances
cutaneous manifestations
oral manifestations
what happens with chemotherapy agents for suppression of bone marrow?
increased susceptibility to infection
what gasterointestinal disturbances are ADE with chemotherapy agents
nausea
what are the cutaneous manifestations of chemo agent?
alopecia (NOT AFFECT dental tx)
what are the oral manifestations of chemo agents?
mucositis
what is the term used to describe physiologic programmed cell death?
apoptosis
what is the most common oral complication with chemo?
mucositis
what are the four major concerns with mucositis?
painful
systemic infection
erythema
ulceration
what is the most feared complication of chemo?
fungal infection
what is an oral manifestation that is most frequently cuased by DAN viruses?
Herpes simplex VIRUS infections
what oral manifestation of chemo may reduce platelet formation, inducing thrombocytopenia
hemorrhage
what oral manifestation contributets to pt discomfort and risk of infection and can contribute to oral candidiasis and opportunistic bacterial phatogens?
xerostomia
what are the oral manifestations of chemo? 6
hemorrhage
xerostomia
neurologic compolications of pain and neruopathy
fungal infections
HSV
mucositis
what are the neurologic complications of pain and neuropathy? 3
nucositis, zerostomia and infection
what results in osteonecrosis of jaw, severe oral complications, reduced ability to receive adequate doses of chemotherapy?
poor oral health
what must be done BEFORE chemotherapy?
thorough oral exam with clinical and radographic eval
Before chemo a dental exam should be done with _____ and _____ care
surgical and restorative care
what DH tx should be done before chemo?
periodontal exam and tx, with oral instructions
during therapy all surgical procedures and hygiene appointment treated _____ days before ____