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Pharmacology Final
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Testosterone is responsible for
secondary male sex characteristics
maturation of sperm
promotion of protein biosynthesis
inhibition of gonad regulation cycle (- feedback)
Conjugated Estrogens (Premarin) indications
symptoms of menopause
prevention of post menopausal osteoporosis
androgen dependent prostate carcinoma
breast cancer (palliation only)
Contraindications for Premarin
associated with increased risk for MI and stroke
VT and PE risk
HTN/vascular diseases
Diabetes
Hypercholesterolemia
Lupus
Drugs that increase elimination of estrogen
warfarin
rifampin
barbiturates
carbamazepine
phenytoin
griseofulvin
st. john's wort
primidone
Drugs that reduce elimination of estrogens by the liver
erythromycin
ketoconazole
itraconazole
ritonavir
Estradiol indications
symptoms of menopause
prevention of bone fractures associated with osteoporosis
Contraindications for estradiol
asthma
breast cancer
breast feeding
CV disease
Drug interactions with estradiol
amoxicillin/ampicillin
protease inhibitors
Methyltestosterone uses
testosterone hormone replacement
breast cancer
post partum breast pain
Warnings with methyltestosterone
can cause hypercalcemia in breast cancer pt
prolonged use may result in hepatitis or hepatic neoplasms
jaundice
prostatic hypertrophy in geriatric pt.
ADEs in women taking methyltestosterone
amenorrhea/irregularities
inhibition of gonadotropin release
virilization
ADEs in men taking methyltestosterone
gynecomastia
excessive erections
oligospermia at high doses
hirsutism
male pattern baldness
acne
retention of salts and water
Liver ADEs of methyltestosterone
cholestatic jaundice
alterations in liver function tests
suppression of clotting factors 2,5,7 & 10.
increased serum cholesterol
Drug interactions with methyltestosterone
increases effects of anticoagulants
elevastes serum levels of oxyphenbutazone
decreases blood glucose and insulin requirements
Tamoxifen Warnings
can cause hypercalcemia in some breast cancer patients with bone matastases
Tamoxifen drug interactions
increases anticoagulat effects
increased risk of thromboembolic event when used with cytotoxic agents
decreased efficacy when used in combo with antidepressants metabolized by cyp2d6
Author
Rx2013
ID
81657
Card Set
Pharmacology Final
Description
Sex Hormones
Updated
2011-04-25T16:00:25Z
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