Pharmacology Final

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Testosterone is responsible for
- secondary male sex characteristics
- maturation of sperm
- promotion of protein biosynthesis
- inhibition of gonad regulation cycle (- feedback)
Conjugated Estrogens (Premarin) indications
- symptoms of menopause
- prevention of post menopausal osteoporosis
- androgen dependent prostate carcinoma
- breast cancer (palliation only)
Contraindications for Premarin
- associated with increased risk for MI and stroke
- VT and PE risk
- HTN/vascular diseases
- Diabetes
- Hypercholesterolemia
- Lupus
Drugs that increase elimination of estrogen
- warfarin
- rifampin
- barbiturates
- carbamazepine
- phenytoin
- griseofulvin
- st. john's wort
- primidone
Drugs that reduce elimination of estrogens by the liver
- erythromycin
- ketoconazole
- itraconazole
- ritonavir
Estradiol indications
- symptoms of menopause
- prevention of bone fractures associated with osteoporosis
Contraindications for estradiol
- asthma
- breast cancer
- breast feeding
- CV disease
Drug interactions with estradiol
- amoxicillin/ampicillin
- protease inhibitors
Methyltestosterone uses
- testosterone hormone replacement
- breast cancer
- post partum breast pain
Warnings with methyltestosterone
- can cause hypercalcemia in breast cancer pt
- prolonged use may result in hepatitis or hepatic neoplasms
- jaundice
- prostatic hypertrophy in geriatric pt.
ADEs in women taking methyltestosterone
- amenorrhea/irregularities
- inhibition of gonadotropin release
- virilization
ADEs in men taking methyltestosterone
- gynecomastia
- excessive erections
- oligospermia at high doses
- hirsutism
- male pattern baldness
- acne
- retention of salts and water
Liver ADEs of methyltestosterone
- cholestatic jaundice
- alterations in liver function tests
- suppression of clotting factors 2,5,7 & 10.
- increased serum cholesterol
Drug interactions with methyltestosterone
- increases effects of anticoagulants
- elevastes serum levels of oxyphenbutazone
- decreases blood glucose and insulin requirements
Tamoxifen Warnings

can cause hypercalcemia in some breast cancer patients with bone matastases
Tamoxifen drug interactions
- increases anticoagulat effects
- increased risk of thromboembolic event when used with cytotoxic agents
- decreased efficacy when used in combo with antidepressants metabolized by cyp2d6

Author

Rx2013

81657

Card Set

Pharmacology Final

Description

Sex Hormones

Updated

2011-04-25T16:00:25Z

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