Dobutamine (Dobutrex)

Sympathetic agonist

Synthetic catecholamine, primarily acts on Beta One receptors but is less potent Beta agonist than Isoproterenol.

Increase force of systolic contraction with little chronotropic activity.

• Onset: 2-10min
• Peak: 10-20 min
• Duration: Varies
• Half-Life: 2 min

Short term management of CHF when an increase in cardiac output is desired not an increased cardiac rate

Only used in as sole agent in hypovolemic shock if fluid resuscitation is well under way, Dopamine is preferred for increased cardiac output.

Ventricular irritability, caution following MI, can be deactivated by alkaline solutions, Increase workload and oxygen demand on the heart.

Headache, HTN, Palpitations.

2.5-20ug/kg/min

2-20 ug/kg/min

See Above

IV Drip

250 mg placed in 500 ml of D5W is concentrations of .5mg/ml