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Midazolam
Trade Name
Versed
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Midazolam
Class
Short-acting benzodiazepine CNS depressant
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Midazolam
Mechanism of Action
- Anxiolytic and sedative properties similar to other benzodiazepines
- Memory impairment
-
Midazolam
Indications
- Sedation
- Anxiolytic prior to endotracheal or nasotracheal intubation
- Conscious sedation
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Midazolam
Contraindications
- Glaucoma
- Shock
- Coma
- Alcohol intoxication
- Overdose patient
- Depressed vital signs
- Concomitant use with other CNS depressants (barbiturates, alcohol, narcotics)
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Midazolam
Adverse Reactions
- Hiccough
- Cough
- Over-sedation
- Nausea
- Vomiting
- Injection site pain
- Headache
- Blurred vision
- Hypotension
- Respiratory depression and arrest
-
Midazolam
Drug Interactions
Should not be used in patients who have taken CNS depressant
-
Midazolam
How Supplied
- 2, 5, 10 ml vials (1 mg / ml ).
- 1, 2, 5, 10 ml vials (5 mg/ ml ).
-
Midazolam
Dosage and Administration
Adult
0.5 - 2.5 mg slow IV push; (may be repeated to total maximum: 0.1 mg / kg)
-
Midazolam
Dosage and Administration
Pediatric
- To facilitate intubation, Medical control may order:
- -(6 months-5 years) Use of Midazolam 0.05-0.1 mg/kg IV maximum dose of 5 mg.
- -(6-12 year old) Use of Midazolam 0.1 mg/kg IV maximum dose of 8 mg.
-
Midazolam
Duration of Action
- Onset: 1-3 minutes IV and dose dependent.
- Peak effect: variable.
- Duration: 2-6 hours and dose dependent
-
Midazolam
Special Considerations
- Pregnancy safety: Category D
- Administer immediately prior to intubation procedure.
- Requires continuous monitoring of respiratory and cardiac function.
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