Home
Flashcards
Preview
ARV Drug interactions
Home
Get App
Take Quiz
Create
Antacids and PPI
Decreases effect of Atazanavir
H2 blocker
: separate use by 10 hours
Antacids
: separate use by 2 hours
Empty stomach
Didanosine
Indinavir
Take with food
PIs except Indinavir
Avoid high fat meal
Efavirenz
Amprenavir
Take with fatty meals
Tenofovir
Nelfinavir
No food effect
NRTI
Darunavir
Increased AUC with food and ritonavir by 30%
Etravirine
Fasting decreased absorption by 50%
Maraviroc
AUC decreased 50% with food
Raltegravir
No effect by food
Lipid lowering agents
Use pravastatin or rosuvastatin
Atorvastatin with low dose and careful monitoring
Anti-TB
Rifampin
Midazolam, triazolam
Use with caution and low dose
SSRI
Fluoxetine can cause serotonin syndrome
Use citalopram or escitalopram
Trazadone
Use lowest dose and monitor CNS and CV effects
Neurlopetics
Variable effects
Titrate to response
Others
Ergot alkaloids
Antihistamines - astimazole
Carbamazepine
Monitor levels
Lamotrigine
Titrate to effect due to decrease levels
Phenytoin
Dual interaction
Use alternative
Valproic acid
Dual interaction
Monitor levels
Oral contraceptive
Ethinyl estradiol and norethindrone decrease AUC
Methadone
Increase levels to avoid withdrawal
Erectile dysfunction agents
Cut dose by 50% with PIs
St. John's Wort
Decreased Indinavir
Fluticasone
Combination with Ritonavir increases concentration of fluticasone
Author
pdnguyen
ID
80843
Card Set
ARV Drug interactions
Description
ARV Drug interactions
Updated
2011-04-20T13:57:41Z
Show Answers
Home
Flashcards
Preview