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Docosanol
- Inhibit adsorption and fusion
- Modify cell membrane by making them rigid
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Adamantes
- Inhibit viral uncoating
- Mimic H+
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Acyclovir, Ganciclovir, Cidofovir
- Inhibiting viral nucleic acid replication through sugar modification
- Mimics dGTP DNA chain terminator
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Brivudin, Idoxuridine, Trifluridine
- Inhibiting viral nucleci acid replication through base modification
- Causes mis-translation --> competitive inhibitor of DNA polymerase
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Foscarnet
- Inhibit viral nucleic acid replication through non-nucleoside DNA polymerase inhibitor
- Prevents cleavage of pyrophosphate from dNTPs during chain elongation process
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Ribavirin
- Inhibit viral nucleic acid replication through RNA polymerase inhibition
- monophosphate inhibits inosine monophosphate dehydrogenase --> depletion of GTP
- di & tri phosphate inhibits viral RNA polymerase
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Raltegravir
Inhibition of integrase activity
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Zanamivir, Oseltamivir
Inhibit viral penetration and budding through neuraminidase/sialidase activity
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Interferon
Inhibiting viral processing through IFN-alpha and IFN-beta
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Antisense agents
Synthetic oligonucleotide expected to seek target site --> hypridize with it --> inhibit the normal function ofthe particular DNA or RNA segment.
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