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Histamine/Seratonin

  1. In which type of immediate hypersensitivity reaction is Histamine released?
    IgE
  2. What are the 4 major responses of Histamine release?
    • 1. Edema
    • 2. Capillary permeability
    • 3. Bronchoconstriction
    • 4. Decrease Pa
  3. What are the Histamine receptors?
    • H1
    • H2
    • H3
    • H4 (don't need to know)
  4. What type of receptors are Histamine receptors?
    All GCPRs
  5. Which receptor(s) stimulate PLC and PLA2?
    H1
  6. What does H2 do?
    Stimulates Adenylyl Cyclase ==> increases cAMP==>vasodilation
  7. What does H3 do?
    Counteracts H1 response by decreasing Ca.
  8. Which receptor is Rapid and short lived?
    H1
  9. Which histamine receptor is slower and sustained?
    H2
  10. Which histamine receptor is responsible for capillary permeability?
    H1
  11. Which AT, V, and B receptors have similar action as H1?
    • AT1
    • V1
    • B2
  12. What affect does H1 receptor have on GI and bronchiolar smooth muscle?
    Contraction
  13. What 3 H1 Histamine antagonists give you marked sedation?
    • 1. Diphenhydramine
    • 2. Meclizine
    • 3. Promethazine
  14. Which 4 H1 Histamine antagonist drugs are anti-motion sickness drugs?
    • 1. Diphenhydramine
    • 2. Cyclizine
    • 3. Meclizine
    • 4. Astemizole
  15. Which H1 histamine antagonist is a component of "sleep aids"?
    Pyrilamine
  16. Which 4 H1 antgagonists provide little to slight sedation?
    • 1. Cyclizine
    • 2. Astemizole
    • 3. Terfenadine
    • 4. Loratadine
  17. What are side effects of H1 antagonists?
    • Sedation (esp with ethanolamines[diphenhydramine])
    • GI disturbances (wicked-bad ones [noisy ones])
  18. What are the 4 2nd generation H1 antagonists?
    • 1. Terfenadine
    • 2. Astemizole
    • 3. Loratadine
    • 4. Flexofenadine
  19. Which 2 2nd gen H1 antagonists may lead to leathal polymorphic ventricular tachycardias?
    • 1. Astemizole
    • 2. Terenadine
  20. Which 2 H1 antagonist have L/A effects?
    • 1. Promethazine
    • 2. Pyrilamine
  21. Which Seratonin receptor is the only non-GPCR? What kind is it?
    5-HT3, a Ligand gated cation channel receptor
  22. What are the 4 actions of of Seratonin on the CV system?
    • 1. Direct vasoconstriction of VSM
    • 2. Indirect vasodilation
    • 3. Platelet aggregation
    • 4. Bezold-Jarisch Reflex
  23. What is the action of seratonin on Smooth muscles?
    • contracts GI and Bronchiolar muscles
    • Diarrhea
  24. What are 5 serotonin receptor antagonists?
    • 1. Cyproheptadine
    • 2. Ketanserin
    • 3. Ergonovine
    • 4. Methysergide
    • 5. Ergotamine
  25. What are 2 Serotonin aonists?
    • 1. sumatriptan
    • 2. zolmitriptan
Author
mexident82
ID
80748
Card Set
Histamine/Seratonin
Description
Amines, histamines, seratonin and antagonists.
Updated

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