In which type of immediate hypersensitivity reaction is Histamine released?
What are the 4 major responses of Histamine release?
2. Capillary permeability
4. Decrease Pa
What are the Histamine receptors?
H4 (don't need to know)
What type of receptors are Histamine receptors?
Which receptor(s) stimulate PLC and PLA2?
What does H2 do?
Stimulates Adenylyl Cyclase ==> increases cAMP==>vasodilation
What does H3 do?
Counteracts H1 response by decreasing Ca.
Which receptor is Rapid and short lived?
Which histamine receptor is slower and sustained?
Which histamine receptor is responsible for capillary permeability?
Which AT, V, and B receptors have similar action as H1?
What affect does H1 receptor have on GI and bronchiolar smooth muscle?
What 3 H1 Histamine antagonists give you marked sedation?
Which 4 H1 Histamine antagonist drugs are anti-motion sickness drugs?
Which H1 histamine antagonist is a component of "sleep aids"?
Which 4 H1 antgagonists provide little to slight sedation?
What are side effects of H1 antagonists?
Sedation (esp with ethanolamines[diphenhydramine])
GI disturbances (wicked-bad ones [noisy ones])
What are the 4 2nd generation H1 antagonists?
Which 2 2nd gen H1 antagonists may lead to leathal polymorphic ventricular tachycardias?
Which 2 H1 antagonist have L/A effects?
Which Seratonin receptor is the only non-GPCR? What kind is it?
5-HT3, a Ligand gated cation channel receptor
What are the 4 actions of of Seratonin on the CV system?
1. Direct vasoconstriction of VSM
2. Indirect vasodilation
3. Platelet aggregation
4. Bezold-Jarisch Reflex
What is the action of seratonin on Smooth muscles?
contracts GI and Bronchiolar muscles
What are 5 serotonin receptor antagonists?
What are 2 Serotonin aonists?
Amines, histamines, seratonin and antagonists.