Psychotropic Drugs

  1. Standard antipsychotic drugs are also called
    • Dopamine Receptor Antagonists
    • neuroleptics
  2. What is an example of a low potency neuroleptic and why is it used less frequently than high potency?
    Low-potency neuroleptics such as chlorpromazine (Thorazine) are used less frequently than high-potency neuroleptic medications because of problems with orthostatic hypotension.
  3. What are 2 high potency neuroleptics?
    • haloperidol (Halidol)
    • fluphenazine (Prolixin)
  4. ** high-potency drugs have less sedation and fewer anticholinergic effects, they cause more EPS than low-potency agents.
  5. What is Neuroleptic Malignant Syndrome?
    Severe muscle rigidity with confusion, agitation, increased temperature, pulse, and blood pressure suggest a serious condition—
  6. Atypical Antipsychotic Drugs are aka
    serotonin-dopamine antagonists (SDAs)
  7. Clozapine
    • Clozapine (SDA) is relatively free of motor side effects
    • is indicated for severely ill schizophrenic individuals who have failed to respond to standard therapy.
    • Clozapine is not used as a first-line treatment because it may suppress bone marrow
  8. The Blocking of dopamine reduces
    the positive symptoms of schitzophrenia
  9. Positive Symptoms of Schitzophrenia
    • ¡Hallucinations-distortion of perceptions
    • ¡Delusions-distortion of thought content
    • ¡Disorganized speech
    • ¡Grossly disorganized or catatonic behaviors
  10. Negative symptoms of Schitzophrenia
    • ¡Apathy (suppression of emotions)
    • ¡Alogia (inablility to speak)
    • ¡Lack of motivation
    • ¡Blunted /flat affect (failure to express feelings)
    • ¡Loss of emotional warmth
    • ¡Impaired social skills
  11. (-) symptoms are treated with ?
    (+) symptoms are treated with ?
    • (-) a typical antipsychotics
    • (+) Hospitalization, Atypical antipsychotics and typical antipsychotics, Reduced stimuli, Interactive therapy
  12. What are the major side effects of Typical Antipsychotics?
    Major Side Effects: dopamine blockage (EPS), noradrenergic (Alpha 1)blockage, cholinergic blockage
  13. What are some atypical antipsychotic examples?
    • ¡Clozapine (Clozaril)
    • ¡Risperidone (Risperdal)
    • ¡Olanzapine (Zyprexa)
    • ¡Quetiapine (Seroquel)
    • ¡Ziprasidone (Geodon)
    • ¡Aripiprazole (Abilify)
  14. What is the tx for NMS?
    • ¡D/C antipsychotics
    • ¡Hydrate
    • ¡Acetaminophen
    • ¡Heparin
    • ¡Dantrolene- antidote for hyperthermia
    • ¡Dopaminergics -Bromocriptine, amantadine
  15. Risperidol has a high risk of
    • EPS
    • orthostatic hypotension
    • weight gain, sedation
Card Set
Psychotropic Drugs
Quiz 1