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Name the 5 HMG-CA reductase inhibitors
- Atorvastatin
- Rosuvastatin
- Simvastatin
- Lovastatin
- Pravastatin
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Lovastatin (2)
Mevacor, Altoprev
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Fibirc Acid Derivatives (2)
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Niacin + simvastatin
Simcor ER
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Cholesteroal absorption blockers (2)
- Ezetimibe
- Ezetimibe + simvastatin
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Ezetimibe + simvastatin
Vytorin
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Summary of HMG CoA reductase inhibitor (4)
- Lower LDL
- Take as same time (night)
- DI with CYP3A4 (grapefruit)
- Hepatotoxicity, myopathy, rhabdomyolysis
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Fibric Acid Summary (4)
- Lower TAG
- GI distress
- CYPE2C9 (warfarin)
- hepatotoxicity, myopathy, rhabdomyolysis
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Niacin Summary (4)
- Increase HDL lower TAG
- Main side effect is flushing, use slow release, take at nighttime, or predose with aspirin
- Niaspan best
- bile acide sequestrants decrease drug level
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Cholesterol absorption blockers summary
- Decrease LDL
- Headache, GI distress
- Rhabdomyolysis
- Bile sequestrants
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