SFOS 25

Right and left coronary trunk arteries

Drains directly into atria

Drains into coronary sinus which empties into right atrium

• Anastomoses of coronary arteries
• Protect against arterial blockage effects

Large vessels on surface of the heart

Precapillary arterioles (resistance vessels)

Oxidative metabolism - i.e. high need for O2 delivery

Discomfort caused by sensory nerve stimulation by metabolite accumulation after myocardial ischemia

• Poor contractility lasting many days
• Result of poor perfusion

• Tissue necrosis due to ischemia
• Permanent myocyte loss - scar tissue develops

• Reversible deterioration of myocytes due to ischemia
• Decreased contractility

• Tension in left ventricule can half coronary perfusion during systole
• Blood flow only in diastole as result

• Vasodilator released in response to shear force
• i.e. blood flow stimulates blood flow

Occluded (full or partial) coronary vessels

• Decreased arterial pressure
• Thrombosis
• Coronary artery spasm

• Thrombolysis
• Coronary collateral formation
• Arterial wall remodeling

Stabilize atherosclerotic coronary arteries by:

• Removing fat
• Attenuating scar formation

• Thickened myocytes - outgrow blood supply
• Exertional angina pectoris