ID 2, Exam 2

Ansa Macrolides: Overview
- natural or semi-synthetic
- belong to ansamycin group of antibiotics
- these possess an aromatic ring system spanned by an alaphatic chain/bridge
History
- Semisynthetic derivative of rifamycin B
- first used clinically in 1968
- Rifampin = USAN (United States Adopted Name)
- Rifampicin = INN (International Non-proprietary Name)
Source; Rifamycin B
- Amycolatopsis mediterranei is the source of the rifamycin complex -- Rifamycin A-E
- Rifampin is a semi-synthetic derivative of rifamycin B
- Rifamycin B is preferentially produced by the organism upon addition of sodium diethylbarbiturate to the fermentation medium

Author

mwbora

8012

Card Set

ID 2, Exam 2

Description

Rifampin

Updated

2010-02-24T23:48:08Z

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