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Contraindications for treatment with bupropion?
If patient was on a MAOI in the last 14 days
History of seizures
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Precautions for bupropion?
Psychiatric - may worsen phychiactive conditions
Careful in bipolar - may precipiate mania
Careful in those predisposed to seizures
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Adverse Effects of bupropion?
Insomnia, nightmares, dizziness
Tremor, headache, constipation
Hypertension, suicide idealation
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Dose of bupropion?
150mg once daily in the morning for 3 days, then 150mg twice daily for 7-9 weeks
elderly- 150mg daily for 7-9 weeks
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Counselling for bupropion?
Start bupropion? at least 7 days before quitting smoking
Take in the morning to reduce incidence of sleep disturbances
Side effects - dizziness etc may impair alertness
Drink alcohol in moderation while taking this med - can increase risk of seizures
if you develop a rash, swelling of the mouth or suicide thoughts - tell your doctor.
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Precautions of varenicline?
Psychiatric condition - may be worsened.
Use with nicotine replacement therapy may increase the risk of nausea, headache, dizziness, dyspepsia.
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Adverse effects of varenicline?
Depresson, agitation, suicide idealation.
Nausea (dose related), vomiting, flatulance, insomnia.
AF, palpitations, GORD, increased weight
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Dose of varenicline?
0.5mg once daily for three days, then 0.5mg twice daily for 4 days, then 1mg twice daily for 11 weeks.
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Counselling for vareincline
Start taking this medication a week before stopping smoking as it takes a while to work.
See your doctor if nausea is a problem, may be able to reduce dose.
Stop taking varenicline if you have suicidal thoughts and see your doctor.
Tablets may be tapered off at the end of treatment to prevent a flare of craving.
Don't use nicotine products in conjunction since it may worsen nausea and headache.
Medication may cause dizziness and may affect your concentration.
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