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What is Hematopoiesis?
process by which blood cells form
Note: after birth, about 1000 billion blood cells are created in the bone marrow per day
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What is the bone marrow as the site of hematopoiesis?
red bone marrow generates blood cells (in adults, located in bones of axial skeleton & in epiphysis of humerus & femur. Newborns have only red bone marrow that is replaced by yellow bone marrow during ages 8-18.
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What are the cell lines in blood cell formation?
blood cells arise from blood stem cells or pluripotential hematopoietic stem cells. These cells will divide until they become commited cells & thus differentiate into a specific type of blood cell
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What are blood cells made from and come from?
made from red bone marrow and come from stem cells
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What is the genesis of erythrocytes in cell lines in blood cell formation?
Blood stem cell becomes a myeloid stem cell, MSC give rise to proerythroblast that eventually becomes a nomoblast, then reticulocyte, then erythrocyte
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What is the formation of leykocytes & platelets in cell lines in blood cell formation?
blood stem cells become a myeloid stem cell or lymphoid stem cell. MSC becomes a myeloblast, monoblast, or megakaryoblast, then specialize to for the granular leukocytes, macrophates, or platelets form
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What does the lymphoid stem cell become?
B or T lymphocytes.
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What are blood types determined by?
markers on the surface of red blood cells.
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Type A:
1. Plasma antibodies (fights against)?
2. Can receive blood from?
3. Can donate blood to?
4. RH Factor?
- 1. anti-b
- 2. A,O
- 3. A,B
- 4. A+, A-
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Type B:
1. Plasma antibodies (fights against)?
2. Can receive blood from?
3. Can donate blood to?
4. RH Factor?
- 1. Anti-a
- 2. B,O
- 3. B,AB
- 4. B+,B-
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Type AB:
1. Plasma antibodies (fights against)?
2. Can receive blood from?
3. Can donate blood to?
4. RH Factor?
- 1. none
- 2. AB, AB, O (universal receiver)
- 3. AB
- 4. AB+, AB-
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Type O:
1. Plasma antibodies (fights against)?
2. Can receive blood from?
3. Can donate blood to?
4. RH Factor?
- 1. anti-a & anti-b
- 2. O
- 3.A, B, AB, O (universal donar)
- 4. O+, O-
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What are the disorders of Erythrocytes?
Polycythemia-abdormal excess of RBCs that can be caused by bone marrow cancer. This increase blood viscosity slowling or blocking blood flow. Can be treated by diluting or removing blood
Anemia-abdormally low RBCs or low hemoglobin that may be caused by excessive bleeding, iron deficiency (folic acid or B12 vitamin), excessive distruction of RBCs, or abnormal structure of hemoglobin
Sickle cell disease-inherited abdormality of hemoglibin. the RBCs may block blood vessels & causing pain, strokes, or infections. There are several forms of treatment so the person lives into adult hood
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What are the disorders of Leukocytes?
Leukemia - form of cancer that causes an increase production of WBCs. in all forms, immature WBCs enter blood stream & also take over bone marrow crowding out normal WBCs.
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What are the causes of death in patients with leukemia?
infections & hemorrhaging
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What are the disorders of Platelts?
Thrombocytopenia-abdormally low platelet concentration. Diminished clot formation & internal bleeding
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