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Growth Hormone Disorders

  1. How does GH promote growth?
    By stimulating protein synthesis and cell division
  2. Most of the effects of GH are indirect through what molecule?
    Insulin-like Growth Factor (IGF-1)
  3. What is the most important regulator of postnatal growth?
    IGF-1
  4. Blood levels are ________ in GH deficiency and _______ in GH excess.
    • Low
    • Increased
  5. Why are IGF-1 levels in blood relatively constant throughout the day?
    Because IGF-1 is complexed with IGF Binding Protein 3 (IGFBP-3) and ALS which prolongs half-life
  6. What are the two primary controllers of GH release?
    • GH Releasing Hormone (GHRH)
    • Somatostatin (SS)
  7. What molecule stimulates both the synthesis and secretion of GH?
    GH-releasing Hormone (GHRH)
  8. What molecule inhibits GH release in response to GHRH and to other stimulatory factors such as low blood glucose concentration?
    Somatostatin
  9. What is the release pattern for GH?
    Pulsatile
  10. The target height is below what percentile in Familial Short Stature?
    3rd
  11. What is the effect of a Thyroid Deficiency on Growth Rate? Bone Maturation? Mature Height?
    • Very Slow
    • Very Retarded
    • Reduced
  12. What is the effect of a Thyroid Excess on Growth Rate? Bone Maturation? Mature Height?
    • Mild Acceleration
    • Mild Advancement
    • Normal
  13. What is the effect of a GH Deficiency on Growth Rate? Bone Maturation? Mature Height?
    • Slow
    • Retarded
    • Reduced
  14. What is the effect of a GH Excess on Growth Rate? Bone Maturation? Mature Height?
    • Accelerated
    • Normal
    • Increased
  15. What is the effect of Sex Steroid Deficiency on Growth Rate? Bone Maturation? Mature Height?
    • Normal Prepubertal
    • Low for Pubertal Age
    • Tall-eunichoid
  16. What is the effect of Sex Steroid Excess on Growth Rate? Bone Maturation? Mature Height?
    • Accelerated
    • Marked Advancement
    • Reduced
  17. Short stature is defined as a height below what percentile?
    3rd
  18. This is defined as growing at a rate slow for age (crossing percentiles). This is usually a concern and needs evaluation
    Growth Failure
  19. How is a GH deficiency diagnosed?
    Low IGF-1 & IGFBP-3
Author
julieaburch
ID
79458
Card Set
Growth Hormone Disorders
Description
Growth Hormone Disorders
Updated

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