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Hypoxia
Define hypoxia and possible causes
- Insufficient oxygen to supply tissue needs.
- Possible Causes; Hypovolemia, reduced capillarity, occluded arteries or arterioles, reduced cardiac output, impaired alveolar diffusion, suffocation/asphyxia, apnea, reduced barometric pressure, anaemia.
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Ischemia
Define Ischemia and possible causes
- Insufficient blood flow to supply tissue needs
- Possible causes; hypovolemia, reduced capillarity, occluded arteries or arterioles, reduced cardiac output
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Clincal Hypoxia or Ischemia
Hypovolemia - blood loss
Ischemia
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Ruduced capillarity - (Cancer, rapid growth unsustainable)
Ischemia
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Occluded arteries or arterioles
Atherosclerosis
Ischemia
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Reduced Cardiac Output
Heart Failure
Ischemia
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Impaired Alveolar Diffusion
Chronic Lung Disease
Hypoxia
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HIF
Hypoxia Inducing Factor
- Transciption factor
- Responds to changes in Cell O2
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HIF and cell oxygen sensing
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