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CNS drugs
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Inactivation of Neurotransmitters
Reuptake inhibitors
Enzymatic transformation - degradation
Diffusion
Neurotransmitters - CNS
Ach - acetylcholine
Dopamine
Seratonin
Epinephrin
Histamine
GABA - Gamma Aminobutyric Acid
Glycine
Neurotransmitters - PNS
ACH
Norepinephrine
Epinephrine
Blood-Brain Barrier
Passage is limited to lipide-soluble agents and drugs that cross by way of specific transport systems.
Drugs that are protein bound or are highly ionized cannot cross.
Opioids - side effects / adverse effects
Respiratory depression -
Alway acess respiration
CNS depression - lower seizure threshold, tremors, sedation, disorientation, confusion
Itching, rash, wheal formation - histamine release
GI upset / constipation
Urinary retention / bladder distension
Opioid - Antagonists (for overdose)
Reverx (IV)
Narcan (IV)
ReVia (PO) - antinarcotic / alcohol overdose
Non-Opiod Analgesics
Acetaminophen (Tylenol)
NSAIDS - asprin / ibupropin
Acetaminophen
a) max daily dose
b) antagonist (for overdose)
a) 4000 mg / daily
b) acetylcysteine - mucolytic - breaksdown mucus - admin w/in 24hr to emptied stomach
Acetaminophen - action
Inhibits prostaglandin synthesis
NSAIDS - mechanism of action
Interfers w/ prostaglandin
NSAIDS
a) side effects
b) Overdose / Toxicity
Do not give to children < 16 due to Reye's syndrome
a) GI upset/distress
Bleeding
Renal impairment
b) Tinnitus
Electrolyte imbalances
Hypoglycemia
Author
pkoonce
ID
79233
Card Set
CNS drugs
Description
CNS drugs for NUR 104
Updated
2011-04-13T18:03:29Z
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