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Heredity and gene transfer
- Offspring acquire traits from parents.
- Inheritance of chromosomes with Genes.
- -Genes are segments of DNA that include specific nucleotide sequence (code for proteins/enzymes)
- Traits are the cumulative effect of proteins, meaning different genes, different traits.
- Copying of DNA required so genes can be passed to offspring
- -Egg and sperm transmit these genes (sexual reproduction)
- Offspring get genes from both parents. DNA is subdivided into chromosomes, except mitochondrial and chloroplast DNA.
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Asexual reproduction
- A single individual is the sole parent that passes its genes to offspring and produces clones (genetically identical)
- mitosis and asexual reproduction
- Single-cell organisms divide by copying DNA equally. Somatic products of multicellular organism (buds, fragmentation by mitotic divisions)
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Sexual reproduction and meiosis
- Sexual reproduction results in greater variation and traits than asexual.
- Two parents create different gene combos which requires meiosis to create sperm and egg.
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Homologous chromosomes
Have same length, centromere position
Homologous chromosomes have genes that control same characters except femails have homologous x and x (xx) males have one x and one y (xy) and only small parts of x and y are homologous.
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Sex Chromosomes
- X and Y.
- Men: XY
- Women: XX
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Autosomes
All other chromosomes besides X and Y.
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Human Life cycle and meiosis
- Somatic cell chromosomes include 46 from two sets of 23. Diploid cells produced from mitosis
- Gamete cell chromosomes. Single set of 23. Haploid cells produced by meosis.
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Meiosis
a reducing cell division. Halves the number of chromosomes. Occurs in ovaries and testes.
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Meiosis I
Homologous chromosomes are separated. 1 cell->2 cells
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Synapsis
- Homologs attatched along length
- Produces tetrad- cluster of 4 chromatids
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Chiasmata
- Chromatids cross.
- Trade segments of DNA with eachother
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Independent assortment
- Metaphase 1: Homologs align at plate. Orientation of homologs is random. 2 posibilities for each maternal/paternal pair. 50/50 chance daughter cells get either.
- Possible number of combinations of maternal/paternal chromosomes in gametes 223 ≈ 8 x 106
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Meiosis II
- Sister chromatids are separated. 2 cells -> 4 cells
- Prophase II-spindle forms and attachs to chromosomes
- Metaphase II chromosomes align at metaphase plate
- Anaphase II- sister chromatids separated, move to poles
- Telophase II and cytokinesis- Nuclei form at opposite poles. Four haploid daughter cells produced.
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Products of mitosis vs. meiosis
- Meiosis: chromosome number reduced in daughter cells
- Mitosis: chromosome number stays the same in daughter cells
- Meiosis: 4 daughter cells genetically different from parent and from eachother
- Mitosis: 2 daughter cells genetically identical
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Unique events of meiosis
- Synapsis- duplicated chromosomes with homologs. Tetrad: four associated chromatids. Chiasmata: crossing of non-sister chromatids.
- Metaphase 1: Homologs align in pairs at metaphase plate.
- Anaphase 1: Each homolog moves to opposite pole (sister chromatids remain attached)
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Sources of Genetic Variation
- Interdependent assortment of chromosomes: position of homologs at metaphase 1 is random.
- Crossing-over: Exchange of DNA occurs with chiasmata
- Random Fertilization: Fusion of one egg and one sperm (out of many). Each egg and sperm genetically different.
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Evolutionary adaptation
- Dependent on genetic variation. Individual variation required for population evolution.
- Individuals with favorable traits will survive (dependent on environment). Fittest survivors likely to create more offspring. (traits passed on)
Differential survival changes population. Population changes over time=Evolution.
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