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______ -> ______ -> ______ -> Serotonin
- Dietary Tryptophan
- 5-Hydroxy Tryptophan
- 5-Hydroxytryptamine
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Physiological Roles of Serotonin:
- GIT- Regulates Motility
- CNS- Neurotransmitter
- (Temp, Sleep, Aggression, Sensory, Pain)
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Metabolism of Serotonin
Oxidative Deamination by MOA
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Excretion of Serotonin
Urine
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Rapid Inj of Serotonin=>
- Decreased Arterial Press w/ Bradycardia
- Short period of Pressor Effect
- Prolong Fall in Systemic BP
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Serotonin Receptors:
- 5-HT1 (Gi Coupled)
- 5-HT2 (Gq Coupled)
- 5-HT3 (Ligand Gated Ion Channel)
- 5-HT4 (Gs Coupled)
- ...5-HT7
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Serotonin Agonists in nature=
Ergot Alkaloids (Ergovine)
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Ergot Alkaloid receptors:
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Therapeutic Uses of Serotonin Agonists in nature:
- Control Postpartum Hemorrhage
- Induce Uterine involution
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How does Serotonin increase GI motility*
Increase ACh release from Vagus
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Drugs classified as Serotonin Agonists:
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Therapeutic Uses of Cisapride (3):
- GI stasis
- Reflux Esophagitis
- Constipation/Megacolon (cats)
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Adverse Fx of Cisapride (1):
Diarrhea
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Therapeutic Uses of Metclopramide (3):
- Vomiting
- GI stasis
- Reflux Esophagitis
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Adverse Fx of Metclopramide (2):
- Behavior/Mood
- Constipation
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Serotonin Antagonists
- Cyproheptadine (Periactin)
- Ketanserin
- Methysergide
- Chlorpromazine
- Phenoxybenzamine
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Therapeutic Uses of Cyproheptatine
- Appetite Stimulation
- Feline Asthma
- Pruritis in cats
- Photic Head Shaking in horses
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Adverse Fx of Cyproheptadine
- Sedation
- Anti-cholinergic activity
- Anorexia
- Lethargy
- Polyphagia
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Therapeutic Uses of Ketanserin
- Ergovaline- Induced, severe vasoconstriction
- Reduce Intraocular Pressure (glaucoma)
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Therapeutic Uses of Methysergide
- Migraines
- Carcinoid Syndrome (GIT cancer)
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