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What are the APC's
Dendritic cells (langerhans, interstitial DC's), Monocytes/Macrophages, B-cells, Thymic epithelial cells
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MHC's
1. synonym
2. display what to what
- 1. HLA (Human Leukocyte Antigen)
- 2. peptide antigens to cytotoxic and helper T-cells
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Class 1 MHC
1. chains?
2. Expression
3. Binds
4. for
5. alleles
- 1. 1 variable alpha and 1 non-variable B2
- 2. all nucleated cells
- 3. endogenous peptides
- 4. Cytotoxic T-cells, CD8 binding site
- 5. A, B, C
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Class 2 MHC
1. chains?
2. Expression
3. Binds
4. For
5. Alleles
- 1. variable alpha and B
- 2. APC's
- 3. exogenous peptides
- 4. T-helper cells, CD4 binding site
- 5. DP, DQ, DR
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Cytosolic Pathway is used for which MHC
MHC class 1
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Transporter used in cytosolic pathway to move peptides into RER
TAP transporter
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Endocytic Pathway is used for which MHC
MHC class 2
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Special molecules used in loading MHC class 2
- Invariant chain (hold chains together in RER,
- DM ( assist in loading peptide into MHC
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