-
marked decrease in the number of granulocytes, particularly neutrophils
arganulocytosis
-
lack of development
aplasia
-
small flat hemorrhagic patch on the skin or mucous membrane--bruise
ecchymosis
-
the volume percentage of RBCs in whole blood
hematocrit
-
chemical substance produced in the body that has a specific regulatory effect on certain cells or organs
hormone
-
excess of glucose in the blood
hyperglycemia
-
deficiency of phosphates in the blood
hypophosphatemia
-
accumulation of acid in the body resulting from the accumulation of ketone bodies
ketoacidosis
-
decreased number of neutrophils in the blood
neutropenia
-
parathyroid hormone
parathormone
-
disc shaped structure found in blood; for blood coagulation
platelet
-
blood disorder characterized by purplish or brownish red discolorations caused by bleeding into the skin or tissues
purpura
-
-
reductions of the number of RBCs quantity of hemoglobin, or volume of packed RBCs
anemia
-
formation of a clot
coagulation
-
insoluble protein that is essential to the clotting of blood
fibrin
-
release of hemoglobin from RBCs by destruction of the cells
hemolysis
-
enlargement of the liver
hepatomegaly
-
excess of calcium in the blood
hypercalcemia
-
hormone produced in the pancreas that regulates glucose metabolism and is a major fuel regulating hormone
insulin
-
RBC that is smaller than normal
microcyte
-
abnormal rarefaction of bone
osteoporosis
-
minute red spot on the skin or mucosa caused by the escape of a small amount of blood
petechia
-
increase in the total RBC mass in the blood
polycythemia
-
enlargement of the spleen
splenomegaly
-
decrease in the number of platelets in circulating blood
thrombocytopenia
-
stoppage or cessation of bleeding
hemostasis
-
-
-excess hormone production by the anterior pituitary gland.
-caused most by a benign tumor that produces growth hormone (pituitary adenoma)
-gigantism
-acromegaly
-macroglossia
hyperpituitarism
-
an increase in growth hormone production
gigantism
-
hypersecretion of growth hormone
acromegaly
-
patients have a thickened tongue
macroglossia
-
-aka:"thyrotoxicosis"
-excessive production of thyroid hormone
-more common in women
-causes: hyperplasia of the gland, benign and malignant tumors of the thyroid, pituitary gland disease, metastic tumors
-clinically: rosy complexion, erythema of the palms, excessive sweating, fine hair, exopthalmus
-oral: premature exfoliation in children, osteoporosis and affects alveolar bone, decay and perio disease, burning tongue
hyperthroidism
-
protrustion of the eyeballs
exopthalmus
-
-decreased output of thyroid hormone
-cretinism
-myxedema
-synthroid used for underscretion
hypothyroidism
-
hypothyroidism present during infancy and childhood
cretinism
-
hypothyroidism present in older children and adults
myxedema
-
-excessive secretion of parathyroid hormone (PTH)
-PTH plays an important role in calcium and phosphorus metabolism
-characterized by: elevated blood levels of calcium, low levels of blood phosphorus, abnormal bone metablism
-most common cause: parathroid adeonma
hyperparathyroidism
-
elevated blood levels of calcium
hypercalcenmia
-
low levels of blood phosphorus
hypophosphatemia
-
benign tumor of parathyroid gland
parathyroid adenoma
-
-involoves the beta cells of the pancreas
-chronic disorder of glucose metabloism that is characterized by abnormally high blood glucose levels
-production of ketone acid from the breakdown of fatty tissues is life threatening
-this causes the blood ph to be lowered
diabetes mellitus
-
chronic disorder of glucose metabloism that is characterized by abnormally high blood glucose levels
hyperglycema
-
types of diabetes
insulin dependent (IDDM) type 1, noninsulin-dependent (NIDDM) type 2
-
-autoimmunity leads to the destruction of insulin producing beta cells leading to insulin deficiency
- 5-10& of all diabetes patients
-onset is usually at 20 years
-3 ps: polydipsia,polyuria,polyghagia
-major problem for patients with IDDM is controlling blood glucose levels
-glucose controlled by multiple injections of insulin
insulin dependent IDDM type 1
-
excessive thirst and fluid intake
polydipsia
-
excessive urination
polyuria
-
excessive appetite
polyphagia
-
-increased insulin resistance
-90% of all diabetes patients are this type
-onset usually in their 40s
-obseity is common
-complications are less common
-control blood glucose with diet and weight reduction
-oral medications to lower blood glucose levels
-25-30% of patients with type 2 require insulin injections
noninsulin dependent NIDDM type2
-
-vascular system is the most severely affected
-increased risk for antherosclerosis
-decreased resistance of infection is seen
-poor wound healing
Clinical manifestation of diabetes
-
-candidasis
-xerostomia
-accentuated response to plaque
-ginigiva can be hyperplastic and erythematous
-periodontal disease,mobility,early tooth loss
-slow wound healing-increased susceptibility to infection
-ABC medication, calculus and plaque removal, and effective oral hygiene care as especially important in the management of diavetic patients
oral complications
-
-aka primary adrenal cortical insufficiency
-characterized by an insufficient production of adrenal steroids
-a malignant tumor or TB may be responsible for destruction of the adrenal gland
addisons disease
-
disease characterized by the replacement of bone with abnormal fibrous CT containing calcifications
fibrous dysplasia
-
-most common form characterized by involvement of only bone
-maxilla affected more than mandible
-ribs,femur, and tibia affected
-common in young children n young adults
monostatic fibrous dysplasia
-
-involvement of more than one bone
-more common in children-females
-bones of face, skull, clavicles, and long bones
-skin lesions
-most severe form is albrights syndrome
polyostatic fibrous dysplasia
-
skin lesions
cafe au labit spots
-
menses,pubic hair,and breast development by two years of age
precocious puberty
-
-aka osteitis deformans
-chronic metabolic disease characterized by resorption, osteoblastic, repair, remineralization, of the involved bone
-older men 50s
-maxilla more commonly affected
-enlargement of bone
pagets disease
-
-disease of bone caused by deficiency of calcium over a long period
-in young children-caused by nutritional deficiency of vitamin d-rickets
osteomalacia
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