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What fragment is produced from pepsin cleavage of IgG
F(ab')2
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What fragment is produced from papain cleavage of IgG
2 Fab segments and an Fc fragment
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What are the 6 effector functions of Iggs
- 1. B-lymphocyte activation
- 2. Complement activation
- 3. Neutralization
- 4. Opsonization
- 5. Antibody dependent cell-mediated cytotoxicity (ADCC)
- 6. Mast cell degranulation
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mIg (BCR) is in complex with what?
- a disulfide linked heterodimer called Ig-a/Ig-B
- -this is the signaling portion of the BCR complex
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IgM
1. % total serum
2. Half-life
3. Location
4. Function
- 1. 5-10%
- 2. 5 days
- 3. secretions, BCR on naive B-cells (monomer)
- 4. pentamer, bacterial/viral neutralization, activate complement, secreted during primary response
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IgG
1. % total serum
2. Half-life
3. Location
4. Function
- 1. 80%
- 2. 25 days
- 3. blood, ECF
- 4. bacterial/viral neutralization, ADCC, cross placenta, opsinization, activate complement, memory response
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IgA
1. % total serum
2. Half-life
3. Location
4. Function
- 1. 10-15%
- 2. 6 days
- 3. external secretions (dimeric)
- 4. neutralizing antibody at mucosal surfaces, memory and late primary response
- - highest daily secretion of any antibody
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IgE
1. % total serum
2. Half-life
3. Location
4. Function
- 1. < 1%
- 2. 2-3 days
- 3. blood
- 4. activate mast cells and basophils when crosslinked by antigen, parasite defense (ADCC), memory response
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IgD
1. % total serum
2. Half-life
3. Location
4. Function
- 1. < 1%
- 2. 3 days
- 3. blood
- 4. B cell activation, BCR in naive B cells
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