DIAZEPAM

BENZO

• By intensifying the activity of GABA, it suppresses the spread of
• seizure activity through the motor cortex of the brain.

• It is effective in the management of stress, anxiety, and alcohol withdrawal due
• to its sedative properties.

• Additionally, it is effective as a
• premedication for minor orthopedic procedures due to its skeletal
• muscle relaxant properties,

• and as a premedication for
• cardioversion because it produces amnesia.

1Seizures (status epilepticus)

2To induce sedation prior to painful procedures

3Acute anxiety

Known hypersensitivity,

• shock,
• coma,

acute alcohol intoxication

Can cause local irritation, therefore, use large vein when possible

• Seizure activity may reoccur due to its lipid solubility
• Use with caution in patients with myasthenia gravis,
• impaired renal or hepatic function, obstetrical patients, and the elderly

HD TA ASS EH DNV BVRD

• Hypotension, drowsiness,
• tachycardia, ataxia,
• amnesia, slurred speech,
• edema, headache,
• dizziness, N/V,
• blurred vision, respiratory depression

Effects are enhanced when used in conjunction with

other CNS depressants and alcohol

Cimetidine may increase diazepam plasma levels

Adult: 5 mg IVP, may repeat at 2.5 mg q 5 minutes prn, max 10 mg

Pedi: 0.1 - 0.25 mg/kg IV/IO, maximum single dose 5 mg

• 0.5 mg/kg PR, maximum single dose 10 mg
• may repeat once after 5 minutes

Half-life = 20 - 50 hours

FLUMAZENIL