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Antipsychotic Medication
called neuroleptics . Used to treat psychotic symptoms.
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psychotic symptoms
- hallucinations and delusions-mostly
- Disorganized orincoherent speech,
- Confused thinking,
- Strange, possibly dangerous behavior, Bizarre behavior,
- Slowed or unusual movements,
- Loss of interest in personal hygiene
- Loss of interest in activities.
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Antipsychotic Medication use
- Schizophrenia
- Bipolar
– the manic phase - Agitation
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Mode of Action of Antipsychotic medication
- Block the dopamine receptors in the brain thereby reduce the psychotic symptoms.
- Also blocks chemoreceptors, trigger zone and the vomiting center in the brain thereby producing antiemetic effect
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Typical and Atypical
2 types Antipsychotic
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Typical Antipsychotic
traditional mainstay of antipsychotic treatment
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Atypical Antipsychotic
The atypical (or "novel") neuroleptics, also known as the "newer" drugs. It is more expensive but with less side effect.
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Side effect of Antipsychotic medication
- Anticholinergic effect
- Sedation
- Decrease in sexual interest or ability
- Photosensitivity
- Liver problem
- Weight gain
- Change color of urine pink or orange
- Agranulocytosis
- Extrapyramidal Syndrome
- Tardive dyskinesia
- Parkinsonism
- Dystonia
- Akathisia
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Neuroleptic malignant syndrome
is a neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs.
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General Nursing Intervention on patient taking Antipsychotic
- Monitor vital signs closely
- Monitor serum glucose level
- Administer medication with food and milk to decrease gastric irritation
- The important of taking medication on time and avoid stopping medication abruptly
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Anti-Anxiety Drugs: Minor tranquilizers
Antianxiety drugs are medicines that calm and relax people with excessive anxiety, nervousness, or tension, or for short-term control of phobia disorder
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Types of Antianxiety
benzodiazepam
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Antidote to Benzodiazepine
Flumazenil
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Medication for Insomnia and Anxiety
They act by depressing the reticular activating system (RAS)which is the part of the brain responsible for awake and motivation.
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3 main factor all working in concert to cause depression
biological, genetic, and environmental factors
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Tricyclic Antidepressant
act by blocking the reuptake of norepinephrine and serotonin at the presynaptic neuron thereby making them more available.
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Tricyclic Antidepressant
- Must not be used with alcohol or antihistamine
- (cough mix) as they will cause severe CNS depression.
- Must not be used along with MAOI as they cause
- hypertensive crisis
- They may cause reduction in the effectiveness of
- antihypertensive medication
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Monoamines Oxidase Inhibitors MAOI Side Effect
- Sedation-leading to drowsiness,
- Orthostatic hypotension
- Hypertensive crisis
- Erectile dysfunction
- orgasm difficulty
- Anticholinergic manifestation
- Insomnia- especially -Parnate
- Weight gain
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Monoamines Oxidase Inhibitors MAOI
acts on CNS by increasing concentration of epinephrine, serotonin and dopamine
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Antidote for the hypertensive crisis
Phentolamine (Regitine)
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Selective Serotonin Reuptake Inhibitors
It produces antidepressant effect by inhibiting serotonin uptake and destruction thereby making more serotonin available.
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For patient on SSRI-prozac instruct
them to take medication early in the day to avoid sleep disturbance at night.
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Anti-manic Drug (Mood Stabilizer)
drug used in the treatment of manic phase of bipolar
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Lithium Carbonate
most effective in the treatment of mania.
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Lithium narrow therapeutic range
0.6-1.2 mEq/liter
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side effects of Antianxiety drugs
sedation, drowsiness
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side effects of Antidepressant drugs
- anti-cholinergic effects
- postural hypotension.
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specific problems or concerns for drug therapy Lithium
requires renal function assessment and monitoring of blood level
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specific problems or concerns for drug therapy Phenothiazines
cause extrapyramidal effects (EPS);
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specific problems or concerns for drug therapy Tardive dyskinesia
can be permanent if client is not assessed regularly for signs of tardive dyskinesia!
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specific client teaching for drug therapy Phenothiazines
photosensitivity, need to wear protective clothing, sunglasses.
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specific client teaching for drug therapy MAO inhibitors
dietary restrictions to prevent hypertensive crisis.
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