What is the trademark of Conn's syndrome?
Stimulated H-loss via H/K atpase
What is Type I renal tubular acidosis?
Inactive Na/H antiport (no angiotensin II)
What is Type II renal tubular acidosis?
inactive H-ATPase (lack of aldosterone)
What is Type IV renal tubular acidosis?
because of hyperkalemia and no aldosterone
Also, the enzymes to break down glutamate are shot
What state do volume contraction + Hypokalemia lead to?
What pump is AngII in control of?
What pumps is Aldo in charge of?
Na/K-ATPase = K secretion @ principal cells
H-ATPase = H secretion @ α intercalated cells
What buffer does hypokalemia help activate?
What is hypocholoremia's role in alkalosis?
The person has activated Aldo so there is high Na reabsorption
The Cl- can't be reabsorbed from lumen
Negative lumen = K and H secretion
K and H secretion = hypokalemia and alkalosis
Is Conn's disease saline-resistant or saline-adaptive?
**due to tumor that performs hypersecretion of Aldo