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What is hyposomotic urine?
high water, low solute
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What is hyperosmotic urine?
Low water, high solute
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What are the descending and ascending LOHs permeable to?
- descending LOH: water
- ascending LOH: Na
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Where do the permeable object of the LOH go?
Interstitial fluid (causing it to become very concentrated at the deep portion of the JGA nephron)
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What is the largest osmotic gradient that can be present in the Ascending LOH?
200 mOsm
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What drug blocks the Na, K, 2Cl pump on the apical membrane of the ascending LOH?
Furosemide
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How do solutes and water flow through the ascending/descending vasa recta?
- Descending: NaCl in, H2O out
- Ascending: NaCl out, H2O in
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Is the vasa recta passive or active transport?
Passive
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Is the LOH active or passive?
Active
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What blocks the thiazide Na/Cl transporter in the distal convoluted tubule?
Any thiazide drug
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What is the function of principal cells of the CD?
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What is the role of intercalated cells of the CD?
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What is the function of Amiloride?
block Na/K exchanger in CD = no Na+ reabsorption through principal cells
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