Diabetes Drugs

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What kind of a drug is Lispro Insulin?

Rapid Acting Insulin therapy with peak.
What kind of a drug is Regular Insulin?

Short acting insulin treatment with peak
What kind of a drug is Isophane (NPH)?

An intermediate acting insulin treatment with peak
What kind of a drug is Insulin Glargine?

Long acting insulin treatment with NO peak.
What kind of a drug is Insulin Dentemir?

Long acting insulin treatment with NO peak.
What is the mechanical action of insulin release in the beta cells?
- Increased glucose --> increased ATP syntheis
- Inhibition of K channels --> depolarization of cell
- Increase of Ca2+ --> insulin release
What kind of drug is insulin zinc extended?

Long acting insulin treatment with peak.
What kind of drug is rimonabant?
- Appitite suppresor for DM 2
- CB1 receptor antagonist
What's the mechanism of action of Sulfonylureas?

Inhibit K channel in b-cells --> depolarization --> release of insulin.
What kind of drug is Tolbutamide?

First generation Sulfonyluera (less potent)
What kind of a drug is glyburide?

Second generation sulfonylurea (more potent)
What kind of drug is glipizide?

Second generation sulfonylurea (more potent)
What kind of drug is repaglinide?

Oral; non sulfonylurea with same MoA on K channel to stimulate insulin secretion
What type of drug is acabose?

Inhibition of sucrose breakdown in gut to prevent hyperglycemia following meals (GI discomfort)
What kind of drug is Pioglitazone?
- Increase insulin sensitivity via synthesis of glucose transporters in skeletal muscle and adipose tissue
- Decrease risk of MI & CVA
What's the action of GLP-1?

Glucagon like peptide that stimulates insulin release from B-cells
What kind of drug is Sitagliptin phosphate?

orally active; inhibits degredation of GLP-1 resulting in stimulation of insulin release
What kinf of drug is Metformin?
- Inhibition of liver gluconeogenesis
- Bypass insulin mechanism to produce similar results

Author

eschott

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Card Set

Diabetes Drugs

Description

Drug List

Updated

2011-04-04T21:42:01Z

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