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What Class of drug is Epinephrine?
Epinephrine is a Sympathomimetic
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List the Mechanism of Action for Epinephrine
- 1) Direct acting Alpha & Beta agonist
- 2) Alpha- bronchial, Cutanious, Renal, & Visceral arteriolar vasoconstriction
- 3) Beta 1- Positive intropic & Chronotropic actions increases automaticity
- 4) Blocks histamine release
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List the indications for the use of Epinephrine
- Indications for Epinephrine:1) cardiac arrest (Asystole, PEA, VFib, Pulselessness VTach)
- 2) Severe Bronchospasm
- 3) Asthuma
- 4) Broncholitis
- 5) Anaphylaxis
- 6) Bradyacardia (in infants and children)
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What are the contraindications to using Epinephrine?
- Contraindications are:
- 1) Pulmonary edmea
- 2) Coronary Insufficiency
- 3) Hypertension
- 4) Hypothermia
- 5) Hypovolemic Shock
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List the possible adverse reactions when administaring Epinephrine?
- Adverse reactions could possibly be:
- 1) Hypertension
- 2) Dysrythmia
- 3) Anxiety
- 4) Pulmonary Edema
- 5) Psycho motor aggitation
- 6) Nausea, Angina, Headache, & restlessness
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What are possible drug interactions associated with Epinephrine?
- Possible drug interractions are:
- 1) Epinephrine other sympathomimetic drugs (make more intense)
- 2) Epinephrine is deactivated by Alkaline solutions
- 3) MAOI drugs potentiate Epinephrine
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Dosages and Administration of Epinephrine for an ADULT
- 1) Bronchospasm/respiratory Distress/ Allergic reaction/ anaphylaxis: 0.15 - 0.3 mg (1:1000 concentration) IM autoinjector
- 2) Cardiac: Asystole/ PEA/ VFib/ Pulsessness VTach: 1 mg (1:10,000 concentration) every (q) 3-5 min
- 3) Trach admin if IV/IO not available: 2.0-5.0 mg (1:1000 concentration) every (q) 3-5 min in 10 ml of Normal Saline (NS)
- 4) Bradycardia, Infusion Mix: 1 mg (1:1000 concentration) in 250 ml of Normal saline (NS) this yields 4 mcg/ml, to be run at 2-10 mcg/min
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Dosages and Administration of Epinephrine for a PEDI
- 1) Bronchospasm/ Respiratory/ Allergy/ Anaphylaxis: 0.15 - 0.3 mg (1:1000 concentration) autoinjector
- 2) Croup: 5ml (1:1000 concentration) via nebulizer over 5 - 15 min
- 3) Cardica: Asystole/ PEA/ VFib/ Pulslessness VTach: Standard initial dose 0.01 mg/kg (1:10,000 concentration) every (q) 3-5 min
- 4) Bradycardia: Standard initial dose0.01 mg/kg (1:10,000 concentration) max single dose 0.5 mg
- 5) Infucion mix: 1 mg (1:1000 concentration) in 250 ml of normal saline (NS), this yields 4 mcg/ml, run at 0.1-1.0 mcg/kg/min
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