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Cytogenetic Findings in Soft Tissue Tumors

  1. Alveolar Rhabdomyosarcoma
    • t(2;13)(q35;q14)(PAX3/FKHR)
    • t(1;13)(p36;q14) (PAX7/FKHR)(better prognosis)
  2. Embryonal Rhabdomyosarcoma
    del(11p15) Beckwith-Wiedemann region

    Complex rearrangements
  3. Ewing Sarcoma
    t(11;22)(q24;q12) (EWS/FLI1) in 85%

    Variant 22q12 (EWS) translocations in small %
  4. Synovial Sarcoma
    t(X;18)(p11;q11) involves SYT (18q11) and one of 3 genes at Xp11 (SSX1 in 66%, SSX2 in 33%, SSX4 rarely)
  5. Alveolar Soft Part Sarcoma
    der(17)t(X;17)(p11;q25) (ASPSCR1/TFE3)
  6. Clear Cell Sarcoma
    t(12;22)(q13;q12) (ATF1/EWS)
  7. Desmoplastic Small Round Cell Tumor
    t(11;22)(p13;q11) WT1/EWS)
Author
elzotter
ID
77301
Card Set
Cytogenetic Findings in Soft Tissue Tumors
Description
cytogenetics, molecular, soft tissue tumors
Updated

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