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Myeloid & Lymphoid Neoplasms with Eosinophilia

  1. PDGFRA
    (4q12)
    • Cryptic deletion at 4q12
    • (detect by FISH or RT-PCR)
    • (other 4q12 translocations
    • also reported)

    FIP1L1-PDGFRA

    Imatinib sensitive
  2. PDGFRB
    (5q31-q33)
    • t(5;12)(q31~q33;p12)
    • (other 5q31-q33 also reported)

    ETV6-PDGFRB

    Imatinib sensitive
  3. FGFR1
    Variety of 8p11 translocations

    Various gene fusions

    Not Imatinib sensitive
Author
elzotter
ID
77298
Card Set
Myeloid & Lymphoid Neoplasms with Eosinophilia
Description
cytogenetics, molecular, lymphoma
Updated

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