-
-
t(1;19)(q23;p13)
Children > adults
- Improved with
- intensive chemo
-
t(v;11q23)
MLL (multiple partners)
Infants under 1yr
Poor
-
t(9;22)(q34;q11)
BCR-ABL1*
Adults > children
Poor
* Most childhood ALL involves BCR minor breakpoint region (p190 fusion protein). ~50% adult ALL produce p230 fusion protein present in CML, and remainder produce p190.
-
t(5;14)(q31;q32) (B-ALL with eosinophilia)
IGH@-IL3
Children & adults
Uncertain (few cases reported)
-
Hyperdiploid B-ALL (51-65 Chromosomes)
- • Good prognosis
- • Common in children
- • Associated with gains of particular chromosomes
- (without major structural abnormalities):
- - X, 4, 6, 10, 14, 17, 18 usually gained as trisomies
- - 21 present as either trisomy or tetrasomy in almost all cases
-
Hypodiploid B-ALL (<46 Chromosomes)
- • Poor prognosis
- • Show loss of ≥ 1 chromosome
- • Ranges from 45 chromosomes to near haploid (23-29 chromosomes)
- • Seen in both adults and children (near haploid appears limited to children )
- • Diagnosis of near haploid or low hypodiploid may be missed by karyotyping because hypodiploid clone can undergo endoreduplicatio (resulting in a near diploid number of chromosomes)
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