-
Alpha receptors
Constriction of blood vessels
-
Beta 1 receptors
- ^ HR
- ^ contractility
- ^ conductivity
-
Beta 2 receptors
- Dilation of bronchi
- Dilation of blood vessels
-
Dopamine
- Sympathomimetics (adrenergic)
- ^ myocardial contractility
- ^HR (more than Dobutamine)
- Dopamine-*Vasoconstriction
-
Dobutamine
- Sympathomimetics (adrenergic)
- ^ myocardial contractility
- ^HR (Dopamine more than Dobutamine)
- Dobutamine- *Vasodilation
-
Hydralazine
- Directly dilates arterial system
- reduces afterload
-
Digoxin
- Cardiac Glycosides
- ^ force and velocity of myocardial contraction
- decreases SA node firing
- ^ refractory period of AV node
- Decreases Artial automaticity
- ^ Ventricular automaticity
- ^ GFR and UOP
-
Nitroglycerin
- Relaxes vascular smooth muscles
- -dilates primarily venous system- decreases preload
- -Dilates arteries at high doses- decreases afterload
- Relieves Vasospasm
- Redistributes blood flow in the heart- improving myocardial O2 consumption
-
Nitroprusside
- Relaxes vascular smooth muscles
- -Dilates venous system- decreases preload
- -Dilates arteries at high doses- decreases afterload
-
Nesiritide (Natrecor)
- Acts as BNP
- Dilates arteries- decreases SVR
- Dilates veins- Decreases PAOP
- Decreased Aldosterone and Norepinepherine levels
- Promotes fluid and sodium release by blocking R-A-A system
-
Calcium Channel Blockers
- Blocks calcium flow through cardiac and smooth muscle cells
- Ex: nifedipine(Procardia), amlodipine (Norvasc), nicardipine (Cardene), diltiazem (Cardizem), Verapamil (Calan)
-
Ace inhibitors
- Vasodilation- block conversion of angiotension I-> Angiotension II (interfere with breakdown of bradykin- produces cough)
- Diuresis- inhibiton of aldosterone (Decreases retention of sodium and water, ^ K retention)
- Ex: Captopril (Capoten), enalapril (Vasotec), lisinopril(Zestril),
-
Angiotension II Blockers
- Cause Vasodilation by blocking angiotension II
- Ex: losartan (Cozar), valsartan (Diovan)
-
Alpha Blockers
- Ex: doxazosin (Cardura)
- prazosin(Minipress), terazosin(Hytrin), phentolamine (Regitine)
-
Alpha and Beta Blockers
- Nonselective blockers
- Ex: Carvedilol (Coreg), labetalol (Normodyne)
-
Phenylephrine(Neo-Synephrine)
- Vasoconsictors
- Stimulates alpha receptors
- - vasoconstricts, ^BP but doesn't ^HR
- -^Aortic root pressure and CAPP
-
Norepinephrine (Levophed)
- Vasoconstrictor
- Stimulates Alpha and Beta receptors
- -Causes vasoconstriction and ^BP w/ minimal ^HR
- - ^Aortic root pressure and CAPP
-
Epinephrine
- Stimulates Alpha and Beta receptors
- -Causes vasoconstriction and ^BP w/ minimal ^HR- ^Aortic root pressure and CAPP
- ^HR and myocardial Conractility
- -acts as histamine antagonist in anahlyaxis
-
Vasopressin (Pitressin)
- ADH
- Reduces portal venous pressure through vasoconstriction
- Increases water reabsorption in renal tubals
- Causes constriction of coronary, splanchic, GI, pancreatic, skin, and muscular vascular beds
|
|
